Pedunculopontine Gamma Band Activity and Development

This review highlights the most important discovery in the reticular activating system in the last 10 years, the manifestation of gamma band activity in cells of the reticular activating system (RAS), especially in the pedunculopontine nucleus, which is in charge of waking and rapid eye movement (RE...

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Published in:Brain sciences 2015-12, Vol.5 (4), p.546-567
Main Authors: Garcia-Rill, Edgar, Luster, Brennon, Mahaffey, Susan, MacNicol, Melanie, Hyde, James R, D'Onofrio, Stasia M, Phillips, Cristy
Format: Article
Language:English
Subjects:
basic rest-activity cycle
Brain research
Ca2+ channels
connexin 36
electrical coupling
Eye movements
parafascicular
preconscious awareness
REM sleep
reticular activating system
Review
Sleep
subcoeruleus
waking
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cited_by cdi_FETCH-LOGICAL-c417t-18699551cdb96338a9e9b15faad44bf5d900de32232904a9e6e3821d12c966963
cites cdi_FETCH-LOGICAL-c417t-18699551cdb96338a9e9b15faad44bf5d900de32232904a9e6e3821d12c966963
container_end_page 567
container_issue 4
container_start_page 546
container_title Brain sciences
container_volume 5
creator Garcia-Rill, Edgar
Luster, Brennon
Mahaffey, Susan
MacNicol, Melanie
Hyde, James R
D'Onofrio, Stasia M
Phillips, Cristy
description This review highlights the most important discovery in the reticular activating system in the last 10 years, the manifestation of gamma band activity in cells of the reticular activating system (RAS), especially in the pedunculopontine nucleus, which is in charge of waking and rapid eye movement (REM) sleep. The identification of different cell groups manifesting P/Q-type Ca(2+) channels that control waking vs. those that manifest N-type channels that control REM sleep provides novel avenues for the differential control of waking vs. REM sleep. Recent discoveries on the development of this system can help explain the developmental decrease in REM sleep and the basic rest-activity cycle.
doi_str_mv 10.3390/brainsci5040546
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subjects basic rest-activity cycle
Brain research
Ca2+ channels
connexin 36
electrical coupling
Eye movements
parafascicular
preconscious awareness
REM sleep
reticular activating system
Review
Sleep
subcoeruleus
waking
title Pedunculopontine Gamma Band Activity and Development
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