Regulation of Biological Functions at the Cell Interface by DNA Nanostructures

The control over specific biological functions of a single cell or between different cells is an exciting goal in the fields of biophysics and biochemistry. Besides the fast‐developed chemical biology methods, such as chemical labeling and gene editing, researchers are still seeking for efficient wa...

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Bibliographic Details
Published in:Advanced NanoBiomed Research (Online) 2022-02, Vol.2 (2), p.n/a
Main Authors: Chen, Yongjian, Tian, Run, Shang, Yingxu, Jiang, Qiao, Ding, Baoquan
Format: Article
Language:English
Subjects:
Antigens
Apoptosis
Biocompatibility
Biological activity
Biophysics
Boolean
Cancer
cell interface
Cells
Communication
Deoxyribonucleic acid
Design
DNA
DNA nanostructures
Drug delivery
Enzymes
Genetic modification
Hybridization
Immunotherapy
Ligands
Medical imaging
Nanomaterials
Nanoparticles
Nanostructure
Proteins
regulation of cell behaviors and functions
Self-assembly
Tumor necrosis factor-TNF
Viruses
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Summary:The control over specific biological functions of a single cell or between different cells is an exciting goal in the fields of biophysics and biochemistry. Besides the fast‐developed chemical biology methods, such as chemical labeling and gene editing, researchers are still seeking for efficient ways to manipulate cell behaviors. Over the past decades, self‐assembled DNA nanostructures have emerged as novel and versatile tools for the study of biological science. Featured with structural programmability, customized functionality, and marked biocompatibility, DNA nanostructures have been immensely exploited for a variety of fascinating biological applications including bioimaging and drug delivery. In addition, DNA nanostructures also hold great potential in the regulation of physiological functions at various biological interfaces. In this minireview, the recent progress of the regulation of biological processes and functions at cell interface using DNA nanostructures is summarized. Current challenges and opportunities in applying DNA nanoassemblies as tools for cell behavior manipulation are also briefly discussed. DNA nanostructures have emerged as versatile platforms for the study of various biological processes. Featured with outstanding self‐assembly and multiple functionalization properties, DNA nanostructures have also been exploited for the regulation of physiological functions at cell interface. This minireview summarizes the recent progress in the regulation of biological processes and the subsequent therapeutic effects at cell interface through DNA nanostructures.
ISSN:2699-9307
2699-9307
DOI:10.1002/anbr.202100126