Interaction between Calpain 5, Peroxisome proliferator-activated receptor-gamma and Peroxisome proliferator-activated receptor-delta genes: a polygenic approach to obesity

Obesity is a multifactorial disorder, that is, a disease determined by the combined effect of genes and environment. In this context, polygenic approaches are needed. To investigate the possibility of the existence of a crosstalk between the CALPAIN 10 homologue CALPAIN 5 and nuclear receptors of th...

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Published in:Cardiovascular diabetology 2008-07, Vol.7 (1), p.23-23
Main Authors: Sáez, María E, Grilo, Antonio, Morón, Francisco J, Manzano, Luis, Martínez-Larrad, María T, González-Pérez, Antonio, Serrano-Hernando, Javier, Ruiz, Agustín, Ramírez-Lorca, Reposo, Serrano-Ríos, Manuel
Format: Article
Language:English
Subjects:
Calpain - genetics
Cross-Sectional Studies
Gene Frequency
Genotype
Humans
Obesity - genetics
Obesity - prevention & control
Original Investigation
Polymorphism, Genetic
PPAR delta - genetics
PPAR gamma - genetics
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Summary:Obesity is a multifactorial disorder, that is, a disease determined by the combined effect of genes and environment. In this context, polygenic approaches are needed. To investigate the possibility of the existence of a crosstalk between the CALPAIN 10 homologue CALPAIN 5 and nuclear receptors of the peroxisome proliferator-activated receptors family. Cross-sectional, genetic association study and gene-gene interaction analysis. The study sample comprise 1953 individuals, 725 obese (defined as body mass index > or = 30) and 1228 non obese subjects. In the monogenic analysis, only the peroxisome proliferator-activated receptor delta (PPARD) gene was associated with obesity (OR = 1.43 [1.04-1.97], p = 0.027). In addition, we have found a significant interaction between CAPN5 and PPARD genes (p = 0.038) that reduces the risk for obesity in a 55%. Our results suggest that CAPN5 and PPARD gene products may also interact in vivo.
ISSN:1475-2840
1475-2840
DOI:10.1186/1475-2840-7-23