Sr/PTA Metal Organic Framework as A Drug Delivery System for Osteoarthritis Treatment

A Sr-based metal-organic framework (MOF) is introduced as ketoprofen carrier to form a comprehensive system for treating osteoarthritis (OA), and the drug loading amount and release rate is investigated. Structural characterization of the samples showed that Sr/PTA-MOF had good crystal morphology an...

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Bibliographic Details
Published in:Scientific reports 2019-11, Vol.9 (1), p.17570-7, Article 17570
Main Authors: Li, Zhen, Peng, Ying, Xia, Xingyu, Cao, Zhe, Deng, Yuqing, Tang, Bin
Format: Article
Language:English
Subjects:
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Anti-Inflammatory Agents, Non-Steroidal - administration & dosage
Anti-Inflammatory Agents, Non-Steroidal - therapeutic use
Arthritis
Chondrocytes
Chondrocytes - drug effects
Chromatography, High Pressure Liquid
Cytotoxicity
Drug Carriers
Drug delivery
High-performance liquid chromatography
Humanities and Social Sciences
Humans
Ketoprofen
Ketoprofen - administration & dosage
Ketoprofen - therapeutic use
Liquid chromatography
Metal-Organic Frameworks - ultrastructure
Microscopy, Electron, Scanning
multidisciplinary
Osteoarthritis
Osteoarthritis - drug therapy
Science
Science (multidisciplinary)
Spectroscopy, Fourier Transform Infrared
Strontium
Thermal stability
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Summary:A Sr-based metal-organic framework (MOF) is introduced as ketoprofen carrier to form a comprehensive system for treating osteoarthritis (OA), and the drug loading amount and release rate is investigated. Structural characterization of the samples showed that Sr/PTA-MOF had good crystal morphology and structure, and chemical and thermal stability. Ketoprofen was successfully loaded on the MOF carrier, which had been identified by high performance liquid chromatography (HPLC) and thermogravimetric analysis (TGA). The release experiment manifested that more than 90% of ketoprofen released from Sr/PTA-MOF after 24 h, and ketoprofen delivery was mainly governed by the Higuchi model. Furthermore, cytotoxicity experiment manifested that synthesized MOF carrier had no poisonous effect on OA chondrocytes, which provided a preliminary foundation for the realization of comprehensive treating OA.
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-019-54147-5