Maturation and Emigration of Single-Positive Thymocytes

T lymphopoiesis in the thymus was thought to be completed once it reaches the single positive (SP) stage, a stage when T cells are “fully mature” and waiting to be exported at random or follow a “first-in-first-out” manner. Recent evidence, however, has revealed that the newly generated SP thymocyte...

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Bibliographic Details
Published in:Clinical & developmental immunology 2013-01, Vol.2013 (2013), p.1-11
Main Authors: Xuan, Qun, Lu, Jin, Li, Pingping, Zhang, Shusong, Xu, Xi, Ge, Qing
Format: Article
Language:English
Subjects:
Acquisitions & mergers
Animals
Antigens, CD - metabolism
Cell Differentiation
Cell migration
Cell Movement
Clonal Selection, Antigen-Mediated
Humans
Immune system
Immunology
Lymphocytes
Oxidation-Reduction
Peptides
Phenotype
Review
T cell receptors
T-Lymphocyte Subsets - cytology
T-Lymphocyte Subsets - metabolism
Thymocytes - cytology
Thymocytes - physiology
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Summary:T lymphopoiesis in the thymus was thought to be completed once it reaches the single positive (SP) stage, a stage when T cells are “fully mature” and waiting to be exported at random or follow a “first-in-first-out” manner. Recent evidence, however, has revealed that the newly generated SP thymocytes undergo a multistage maturation program in the thymic medulla. Such maturation is followed by a tightly regulated emigration process and a further postthymic maturation of recent thymic emigrants (RTEs). This review summarizes recent progress in the late stage T cell development. The regulation of this developmental process is discussed.
ISSN:2314-8861
1740-2522
2314-7156
1740-2530
DOI:10.1155/2013/282870