Bacterial findings in patients referred to hospital for the treatment of acute tonsillitis with or without peritonsillar phlegmon

The vast majority of patients with acute tonsillitis (AT) are managed in general practice. However, occasionally patients are referred to hospital for specialized management because of aggravated symptoms and/or findings suggestive of peritonsillar involvement. No prospective studies have been condu...

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Bibliographic Details
Published in:BMC infectious diseases 2023-06, Vol.23 (1), p.439-439, Article 439
Main Authors: Andersen, Camilla, Greve, Thomas, Reinholdt, Kasper Basse, Kjaerulff, Ann Marlene Gram, Udholm, Nichlas, Khalid, Vesal, Madzak, Adnan, Duez, Christophe, Münch, Henrik, Pauli, Søren, Danstrup, Christian Sander, Petersen, Niels Krintel, Klug, Tejs Ehlers
Format: Article
Language:English
Subjects:
Age
Antibiotics
Antigens
Bacteria
Care and treatment
Cellulitis
Cellulitis - epidemiology
Diagnosis
Dosage and administration
Dysbacteriosis
Fusobacterium necrophorum
Hospital patients
Hospitals
Humans
Infections
Infectious diseases
Information and referral services
Ions
Microorganisms
Otolaryngology
Pathogens
Patients
Penicillin
Prevotella
Streptococcus dysgalactiae
Streptococcus infections
Streptococcus pyogenes
Testing
Throat surgery
Tonsillitis
Tonsillitis - epidemiology
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Summary:The vast majority of patients with acute tonsillitis (AT) are managed in general practice. However, occasionally patients are referred to hospital for specialized management because of aggravated symptoms and/or findings suggestive of peritonsillar involvement. No prospective studies have been conducted aiming to investigate the prevalent and significant microorganisms in this highly selected group of patients. We aimed to describe the microbiological findings of acute tonsillitis with or without peritonsillar phlegmon (PP) in patients referred for hospital treatment and to point out potential pathogens using the following principles to suggest pathogenic significance: (1) higher prevalence in patients compared to healthy controls, (2) higher abundance in patients compared to controls, and (3) higher prevalence at time of infection compared to time of follow up. Meticulous and comprehensive cultures were performed on tonsillar swabs from 64 patients with AT with (n = 25) or without (n = 39) PP and 55 healthy controls, who were prospectively enrolled at two Danish Ear-Nose-Throat Departments between June 2016 and December 2019. Streptococcus pyogenes was significantly more prevalent in patients (27%) compared to controls (4%) (p 
ISSN:1471-2334
1471-2334
DOI:10.1186/s12879-023-08420-8