Therapeutic strategy for pandrug-resistant Klebsiella pneumoniae severe infections: short-course treatment with colistin increases the in vivo and in vitro activity of double carbapenem regimen

Highlights • Therapeutic options in pandrug-resistant (PDR) Klebsiella pneumoniae infections are limited. • The double carbapenem regimen has been proposed as a therapeutic option. • A PDR K. pneumoniae bloodstream infection was treated successfully with colistin plus meropenem and ertapenem. • The...

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Bibliographic Details
Published in:International journal of infectious diseases 2015-04, Vol.33 (C), p.132-134
Main Authors: Oliva, Alessandra, Mascellino, Maria T, Cipolla, Alessia, D’Abramo, Alessandra, De Rosa, Annalisa, Savinelli, Stefano, Ciardi, Maria Rosa, Mastroianni, Claudio M, Vullo, Vincenzo
Format: Article
Language:English
Subjects:
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Anti-Bacterial Agents - pharmacology
Anti-Bacterial Agents - therapeutic use
Bacterial Proteins - genetics
Bacterial Proteins - metabolism
beta-Lactam Resistance - genetics
beta-Lactamases - genetics
beta-Lactamases - metabolism
Bloodstream infection
Carbapenems - pharmacology
Carbapenems - therapeutic use
Colistin
Colistin - pharmacology
Colistin - therapeutic use
Double carbapenem
Drug Resistance, Multiple, Bacterial - genetics
Drug Synergism
Drug Therapy, Combination
Female
Humans
Infectious Disease
Klebsiella Infections - drug therapy
Klebsiella pneumoniae - drug effects
Klebsiella pneumoniae - enzymology
Klebsiella pneumoniae - genetics
Microbial Sensitivity Tests
Pan-drug resistant K. pneumoniae
Pulmonary/Respiratory
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Summary:Highlights • Therapeutic options in pandrug-resistant (PDR) Klebsiella pneumoniae infections are limited. • The double carbapenem regimen has been proposed as a therapeutic option. • A PDR K. pneumoniae bloodstream infection was treated successfully with colistin plus meropenem and ertapenem. • The colistin plus double carbapenem regimen showed bactericidal and synergistic effect against PDR K. pneumoniae.
ISSN:1201-9712
1878-3511
DOI:10.1016/j.ijid.2015.01.011