Ursodeoxycholic Acid May Inhibit Environmental Aging-Associated Hyperpigmentation

Extrinsic aging of the skin caused by ultraviolet (UV) light or particulate matter is often manifested by hyperpigmentation due to increased melanogenesis in senescent skin. Ursodeoxycholic acid (UDCA), which has been commonly used as a health remedy for liver diseases, is known to possess antioxida...

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Bibliographic Details
Published in:Antioxidants 2021-02, Vol.10 (2), p.267
Main Authors: Moon, Ik Jun, Yoo, Hanju, Paik, Seung Hwan, Kim, Hak Tae, Kim, Su Yeon, Song, Youngsup, Chang, Sung Eun
Format: Article
Language:English
Subjects:
Acids
Aging
antioxidant
Antioxidants
Collagen (type I)
Cyclooxygenase-2
environmental aging
Fibroblasts
Hyperpigmentation
Inflammation
Interleukin 8
Liver diseases
Matrix metalloproteinase
Melanin
Melanocytes
Oxidative stress
Particulate matter
Phenotypes
photoaging
Pollutants
Prostaglandin endoperoxide synthase
Proteins
Senescence
Skin
Tumor necrosis factor-α
Ultraviolet radiation
Ursodeoxycholic acid
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Summary:Extrinsic aging of the skin caused by ultraviolet (UV) light or particulate matter is often manifested by hyperpigmentation due to increased melanogenesis in senescent skin. Ursodeoxycholic acid (UDCA), which has been commonly used as a health remedy for liver diseases, is known to possess antioxidant properties. This study was done to investigate whether UDCA inhibits cellular aging processes in the cells constituting human skin and it reduces melanin synthesis. ROS, intracellular signals, IL-1α, IL-8, TNF-α, cyclooxygenase (COX)-2, type I collagen, and matrix metalloproteinases (MMPs) levels were measured in human dermal fibroblasts treated with or without UDCA after UV exposure. Melanin levels and mechanistic pathways for melanogenesis were investigated. UDCA decreased ROS, senescence-associated secretory phenotype (SASP), and proinflammatory cytokines induced by UV treatment. UDCA reduced melanogenesis in normal human melanocytes cocultured with skin constituent cells. Our results suggest that UDCA could be a comprehensive agent for the treatment of environmental aging-associated hyperpigmentation disorders.
ISSN:2076-3921
2076-3921
DOI:10.3390/antiox10020267