The Roles of Histone Lysine Methyltransferases in Heart Development and Disease

Epigenetic marks regulate the transcriptomic landscape by facilitating the structural packing and unwinding of the genome, which is tightly folded inside the nucleus. Lysine-specific histone methylation is one such mark. It plays crucial roles during development, including in cell fate decisions, in...

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Bibliographic Details
Published in:Journal of cardiovascular development and disease 2023-07, Vol.10 (7), p.305
Main Authors: Zhu, Jun-Yi, van de Leemput, Joyce, Han, Zhe
Format: Article
Language:English
Subjects:
cardiac development
Cardiovascular disease
Cell cycle
Congenital diseases
Congenital heart disease
Development and progression
Developmental biology
Epigenetic inheritance
epigenetic regulation
Epigenetics
Gene expression
Genetic aspects
Genetic disorders
Genomes
Genomics
Heart diseases
histone lysine methyltransferase
Hypoxia
Insects
Lysine
Methylation
Methyltransferases
Mutation
Proteins
Review
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Summary:Epigenetic marks regulate the transcriptomic landscape by facilitating the structural packing and unwinding of the genome, which is tightly folded inside the nucleus. Lysine-specific histone methylation is one such mark. It plays crucial roles during development, including in cell fate decisions, in tissue patterning, and in regulating cellular metabolic processes. It has also been associated with varying human developmental disorders. Heart disease has been linked to deregulated histone lysine methylation, and lysine-specific methyltransferases (KMTs) are overrepresented, i.e., more numerous than expected by chance, among the genes with variants associated with congenital heart disease. This review outlines the available evidence to support a role for individual KMTs in heart development and/or disease, including genetic associations in patients and supporting cell culture and animal model studies. It concludes with new advances in the field and new opportunities for treatment.
ISSN:2308-3425
2308-3425
DOI:10.3390/jcdd10070305