Role of advanced glycation end products in cellular signaling

Improvements in health care and lifestyle have led to an elevated lifespan and increased focus on age-associated diseases, such as neurodegeneration, cardiovascular disease, frailty and arteriosclerosis. In all these chronic diseases protein, lipid or nucleic acid modifications are involved, includi...

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Bibliographic Details
Published in:Redox biology 2014-01, Vol.2 (C), p.411-429
Main Authors: Ott, Christiane, Jacobs, Kathleen, Haucke, Elisa, Navarrete Santos, Anne, Grune, Tilman, Simm, Andreas
Format: Article
Language:English
Subjects:
Advanced glycation end products
Age-associated diseases
AGE-receptors
Aggregates
Aging
Aging - physiology
Animals
Bone and Bones - metabolism
Dietary Proteins - adverse effects
Dietary Proteins - pharmacokinetics
Glycation End Products, Advanced - physiology
Humans
Hyperglycemia - metabolism
Immune System - metabolism
Inflammation - etiology
Inflammation - metabolism
Lipid Peroxidation
Lung - metabolism
Maillard Reaction
Models, Biological
Neurons - metabolism
NF-kappa B - physiology
NF-κB
Oxidative stress
Oxidative Stress - physiology
Polymers - metabolism
Protein Aggregates
Protein Transport
RAGE
Reactive carbonyl compounds
Reactive Nitrogen Species - metabolism
Reactive Oxygen Species - metabolism
Receptor for Advanced Glycation End Products
Receptors, Immunologic - physiology
Receptors, Scavenger - physiology
Review
Signal Transduction - physiology
Signaling
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Summary:Improvements in health care and lifestyle have led to an elevated lifespan and increased focus on age-associated diseases, such as neurodegeneration, cardiovascular disease, frailty and arteriosclerosis. In all these chronic diseases protein, lipid or nucleic acid modifications are involved, including cross-linked and non-degradable aggregates, such as advanced glycation end products (AGEs). Formation of endogenous or uptake of dietary AGEs can lead to further protein modifications and activation of several inflammatory signaling pathways. This review will give an overview of the most prominent AGE-mediated signaling cascades, AGE receptor interactions, prevention of AGE formation and the impact of AGEs during pathophysiological processes.
ISSN:2213-2317
2213-2317
DOI:10.1016/j.redox.2013.12.016