The prognostic value of radiomic features from pre- and post-treatment 18F-FDG PET imaging in patients with nasopharyngeal carcinoma

Positron emission tomography/computed tomography (PET/CT) with 18 F-fluorodeoxyglucose (FDG) is widely used for management of nasopharyngeal carcinoma (NPC). Combining the radiomic features of pre- and post-treatment FDG PET images may improve tumor characterization and prognostic predication. We in...

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Bibliographic Details
Published in:Scientific reports 2023-05, Vol.13 (1), p.8462-8462, Article 8462
Main Authors: Kim, Soo Jeong, Choi, Joon Young, Ahn, Yong Chan, Ahn, Myung-Ju, Moon, Seung Hwan
Format: Article
Language:English
Subjects:
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Computed tomography
Humanities and Social Sciences
multidisciplinary
Nasopharyngeal carcinoma
Patients
Population studies
Positron emission tomography
Radiation therapy
Radiomics
Science
Science (multidisciplinary)
Survival
Throat cancer
Tomography
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Summary:Positron emission tomography/computed tomography (PET/CT) with 18 F-fluorodeoxyglucose (FDG) is widely used for management of nasopharyngeal carcinoma (NPC). Combining the radiomic features of pre- and post-treatment FDG PET images may improve tumor characterization and prognostic predication. We investigated prognostic value of radiomic features from pre- and post-radiotherapy FDG PET images in patients with NPC. Quantitative radiomic features of primary tumors were extracted from the FDG PET images of 145 NPC patients and the delta values were also calculated. The study population was divided randomly into two groups, the training and test sets (7:3). A random survival forest (RSF) model was adopted to perform analyses of progression-free survival (PFS) and overall survival (OS). There were 37 (25.5%) cases of recurrence and 16 (11.0%) cases of death during a median follow-up period of 54.5 months. Both RSF models with clinical variables and radiomic PET features for PFS and OS showed comparable predictive performance to RSF models with clinical variables and conventional PET parameters. Tumoral radiomic features of pre- and post-treatment FDG PET and the corresponding delta values may predict PFS and OS in patients with NPC.
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-023-35582-x