High-Dose Deltamethrin Induces Developmental Toxicity in Caenorhabditis elegans via IRE-1

Deltamethrin (DM), a Type II pyrethroid, is widely used worldwide in agriculture, household applications, and medicine. Recent studies have shown that DM exerts a variety of toxic effects on organs such as the kidney, heart muscle, and nerves in animals. However, little is known about the effects of...

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Bibliographic Details
Published in:Molecules (Basel, Switzerland) Switzerland), 2023-08, Vol.28 (17), p.6303
Main Authors: Chen, Chuhong, Deng, Ying, Liu, Linyan, Zou, Zhenyan, Jin, Chenzhong, Chen, Zhiyin, Wang, Shuanghui
Format: Article
Language:English
Subjects:
Animals
Apoptosis
Caenorhabditis elegans
Child development
deltamethrin
development
Endoplasmic reticulum
endoplasmic reticulum unfolded protein response
Investigations
Nematodes
Pesticides
Toxicity
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Summary:Deltamethrin (DM), a Type II pyrethroid, is widely used worldwide in agriculture, household applications, and medicine. Recent studies have shown that DM exerts a variety of toxic effects on organs such as the kidney, heart muscle, and nerves in animals. However, little is known about the effects of high-dose DM on growth and development, and the mechanism of toxicity remains unclear. Using the Caenorhabditis elegans model, we found that high-dose DM caused a delay in nematode development. Our results showed that high-dose DM reduced the activation of the endoplasmic reticulum unfolded protein response (UPRER). Further studies revealed that high-dose DM-induced developmental toxicity and reduced capacity for UPRER activation were associated with the IRE-1/XBP-1 pathway. Our results provide new evidence for the developmental toxicity of DM and new insights into the mechanism of DM toxicity.
ISSN:1420-3049
1420-3049
DOI:10.3390/molecules28176303