Impact of Binet Staging versus Tumour Bulk on Treatment Outcome in Chronic Lymphocytic Leukaemia

• Published in: The Nigerian postgraduate medical journal 2024-01, Vol.31 (1), p.76-80
• Main Authors: Madu, Anazoeze Jude, Okoye, Helen Chioma, Muoghalu, Ebele Adaobi, Ugwu, Angela Ogechukwu, Duru, Augustine Nwakuche, Nonyelu, Charles Emeka, Anigbogu, Ikechukwu Okwudili, Ezekekwu, Chinedu Anthony
• Format: Article
• Language: English
• Subjects: binet stage; Care and treatment; chronic lymphocytic leukaemia; Chronic lymphocytic leukemia; Clinical outcomes; Development and progression; Health aspects; impact; Leukemia; Lymphocytes; Measurement; Patient outcomes; Prognosis; Spleen; treatment outcome; Tumors; tumour bulk
• ISSN: 1117-1936; 2468-6875
• DOI: 10.4103/npmj.npmj_246_23

Most of the predictive tools put up to prognosticate treatment outcomes in patients with chronic lymphocytic leukaemia (CLL) are not easily available and affordable in our resource-constrained environment. The aim of this study was to evaluate the impact of staging and some tumour bulk on treatment outcomes of persons with CLL, Enugu, Nigeria. This is a 10-year review of the CLL data from the haemato-oncology unit of a Nigerian tertiary hospital to evaluate the impact of staging and tumour bulk indicators. Data were retrieved from the case notes of 102 patients with CLL receiving care at the facility. Data of interest include basic demographic variables, clinical features including spleen size and disease staging and blood counts. Statistical analysis was done using SPSS version 22. The median absolute lymphocyte count (ALC) was 108.05 (confidence interval [CI] = 50.8-201.3, interquartile range [IQR] = 124.4) ×109/L, and duration of survival for the study cohort was 5.5 (CI = 3.5-31.9, IQR = 27) months. Majority (69, 79.3%) were in Stage C. The Binet stage showed a significant association with the ALC (r = 0.338; P = 0.002) but not with spleen size (r = 0.198; P = 0.056). The duration of survival only showed a significant inverse relationship with the ALC (r = 0.35, P = 0.006) but with neither the Binet stage (r = 0.103, P = 0.431) nor spleen size (r = 0.184, P = 0.116). In CLL patients, ALC at presentation correlates with the duration of survival. We recommend that the ALC at presentation be used as a prognostic marker in our clime.