2-methoxy-4-(((5-nitropyridin-2-yl)imino)methyl)phenol Schiff base ligand and its Cu(II) and Zn(II) complexes: synthesis, characterization and biological investigations

• Published in: Heliyon 2022-06, Vol.8 (6), p.e09648-e09648, Article e09648
• Main Authors: Deepika, P., Vinusha, H.M., Begum, Muneera, Ramu, Ramith, Shirahatti, Prithvi S., Nagendra Prasad, M.N.
• Format: Article
• Language: English
• Subjects: Antioxidant; free radicals; ligands; Metal complexes; Pyridine based ligand; schiff bases; stoichiometry; TG and DTG; thermogravimetry; vanillin
• ISSN: 2405-8440; 2405-8440
• DOI: 10.1016/j.heliyon.2022.e09648

In this current work we have prepared a Schiff base ligand, (HL) derived from 5- nitropyridine-2-amine with 4-hydroxy-3-methoxybenzaldehyde and its Cu(II), and Zn(II) in 2:1 stoichiometric ratio (2HL:M). The formation of the ligand and the metal complexes were evaluated by means of MS, FT-IR, UV-Visible, 1H-NMR, 13C-NMR and thermogravimetric methods. The free radical scavenging activity of compounds was evaluated through a sequence of in vitro assays viz., DPPH, ABTS and Superoxide where BHA was used as a positive controller. In vitro α-glucosidase inhibitory activities showed that complexes had considerable inhibitory potential when compared to the ligand. [Display omitted] •Synthesis of 2-methoxy-4-(((5-nitropyridin-2-yl)imino)methyl)phenol.•Synthesis of Cu(II) and Zn(II) complexes.•Characterization of compounds by using FT-IR, UV-Visible, ​MS, ​ 1 H-NMR,13 C-NMR and TGA.•Antioxidant and α-glucosidase and α-amylase Inhibitory effects were evaluated through different in vitro assays. Pyridine based ligand, Metal complexes, TG and DTG, Antioxidant.