Cross-neutralization of the coagulant activity of Crotalus durissus terrificus venom from the northeast of Argentina by bivalent bothropic antivenom

Cross-neutralization of Crotalus durissus terrificus venom coagulant activity was tested using bivalent horse antivenom against Bothrops alternatus and Bothrops diporus venoms. Our in vitro and in vivo experiments showed that bothropic antivenom neutralizes the thrombin-like activity of crotalic sna...

Full description

Saved in:
Bibliographic Details
Published in:The journal of venomous animals and toxins including tropical diseases 2012, Vol.18 (1), p.116-123
Main Authors: Rodríguez, JP, Gay, CC, Fusco, LS, Gauna, MC, Acosta, OC, Leiva, LC
Format: Article
Language:English
Subjects:
Antivenom
antivenoms
Bothrops
Bothrops alternatus
Coagulants
Cross-reaction
Crotalus durissus terrificus
Enzymes
Immunoassays
immunological cross-reaction
snake venom
thrombin-like enzyme
TOXICOLOGY
TROPICAL MEDICINE
Venom
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Cross-neutralization of Crotalus durissus terrificus venom coagulant activity was tested using bivalent horse antivenom against Bothrops alternatus and Bothrops diporus venoms. Our in vitro and in vivo experiments showed that bothropic antivenom neutralizes the thrombin-like activity of crotalic snake venom and this cross-reaction was demonstrated by immunoassays either with whole venom or a purified thrombin-like enzyme. These results suggest common antigenic properties and, consequently, similar molecular structure among venom thrombin-like enzymes. Besides, they provide information that could be further used in the development of new antivenom formulations.
ISSN:1678-9199
1678-9199
DOI:10.1590/S1678-91992012000100015