Left atrial phasic function remodeling during its enlargement: a two-dimensional speckle-tracking echocardiography study

Left atrial (LA) size is often used as a surrogate marker of LA function in clinical practice, with larger atrial thought to represent a "dysfunctioning" atrium, since there is no accepted 'gold' standard to evaluate LA function. The exact relationship between LA size and phasic...

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Bibliographic Details
Published in:BMC cardiovascular disorders 2022-05, Vol.22 (1), p.231-231, Article 231
Main Authors: Chen, Chuyun, Yang, Ying, Ma, Wei, Qi, Litong, Zhang, Baowei, Zhang, Yan
Format: Article
Language:English
Subjects:
Atrial function
Cardiovascular disease
Cardiovascular diseases
Contractility
Diagnosis
Echocardiography
Enlargement
Heart atrium
Heart attacks
Heart rate
Hypertension
Left atrial remodeling
Medical examination
Obesity
Phasic function
Pulmonary arteries
Regression analysis
Risk factors
Software
Speckle tracking
Stroke
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Summary:Left atrial (LA) size is often used as a surrogate marker of LA function in clinical practice, with larger atrial thought to represent a "dysfunctioning" atrium, since there is no accepted 'gold' standard to evaluate LA function. The exact relationship between LA size and phasic function, and whether LA dysfunction occur before LA enlargement (LAE) may be of clinical interest while have not been fully studied. Two-dimensional speckle-tracking echocardiography (2D STE) was showed a promising method in measuring LA physical deformation. A community cohort of 715 subjects at cardiovascular disease high risk accepted comprehensive echocardiography. LA longitudinal phasic strain Sa (absolute peak strain during atrial contraction), Se (peak strain at early diastole) and Stot (total atrial strain = Sa + Se), representing contractile, conduit, and reservoir function respectively, were measured using off-line 2D STE software in apical 4 chamber view, and data were compared among groups at different LA size and between subgroups in normal LA size with and without hypertension (HT). With LAE (from normal size, mild, moderate to severe LAE), the Stot (21.74 ± 5.97, 20.75 ± 4.99, 20.49 ± 5.27, 17.75 ± 4.71, respectively, ANOVA P = 0.003) and Sa (11.84 ± 3.92, 11.00 ± 3.29, 10.11 ± 2.57, 8.55 ± 2.88, respectively, ANOVA P 
ISSN:1471-2261
1471-2261
DOI:10.1186/s12872-022-02672-z