Experience with the ketogenic diet in premature neonates

The ketogenic diet is a time‐tested, potent, nonpharmacological treatment of epilepsy. However, the use of the ketogenic diet in premature neonates with epilepsy has not been previously reported. We share our experience with the use of ketogenic diet therapy in two premature neonates. Two identical...

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Published in:Epilepsia open 2023-03, Vol.8 (1), p.200-204
Main Authors: Phitsanuwong, Chalongchai, Kim, Jeong‐A, Schimpf, Stephanie, Nordli, Douglas R.
Format: Article
Language:English
Subjects:
Age groups
Calories
Cardiac arrhythmia
Case reports
Convulsions & seizures
Diet
Diet, Ketogenic - adverse effects
Electroencephalography
Epilepsy
Epilepsy - drug therapy
Humans
Hypoglycemia
Infant
Infant, Newborn
ketogenic diet
Ketone Bodies - therapeutic use
Ketosis
neonate
newborn
Nutrition research
Patients
premature
preterm
Short
Short s
Treatment Outcome
Twins
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creator Phitsanuwong, Chalongchai
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description The ketogenic diet is a time‐tested, potent, nonpharmacological treatment of epilepsy. However, the use of the ketogenic diet in premature neonates with epilepsy has not been previously reported. We share our experience with the use of ketogenic diet therapy in two premature neonates. Two identical twin premature neonates with SCN2A‐related developmental and epileptic encephalopathy, whose seizures were refractory to multiple anti‐seizure medications, were started on the classic ketogenic diet at the conceptual age of 35 weeks. Ketosis was achieved and maintained (range 2‐5 mmol/L of serum beta‐hydroxybutyrate level). Seizure frequency was significantly reduced (>90% reduction in both patients), and some anti‐seizure medications were able to be discontinued. Initial transient weight loss and one episode of asymptomatic hypoglycemia were observed and corrected. The ketogenic diet was found to be a safe, well‐tolerated, and effective treatment for seizures in two premature neonates. The side effects are tolerable and correctable. The ketogenic diet, therefore, is a treatment option for refractory seizures in this age group, when administered under expert guidance.
doi_str_mv 10.1002/epi4.12673
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source Open Access: PubMed Central; Publicly Available Content Database; Wiley Open Access
subjects Age groups
Calories
Cardiac arrhythmia
Case reports
Convulsions & seizures
Diet
Diet, Ketogenic - adverse effects
Electroencephalography
Epilepsy
Epilepsy - drug therapy
Humans
Hypoglycemia
Infant
Infant, Newborn
ketogenic diet
Ketone Bodies - therapeutic use
Ketosis
neonate
newborn
Nutrition research
Patients
premature
preterm
Short
Short s
Treatment Outcome
Twins
title Experience with the ketogenic diet in premature neonates
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