Plasma fatty acids, oxylipins, and risk of myocardial infarction: the Singapore Chinese Health Study[S]

We aimed to examine the prospective association between plasma FAs, oxylipins, and risk of acute myocardial infarction (AMI) in a Singapore Chinese population. A nested case-control study with 744 incident AMI cases and 744 matched controls aged 47–83 years was conducted within the Singapore Chinese...

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Bibliographic Details
Published in:Journal of lipid research 2016-07, Vol.57 (7), p.1300-1307
Main Authors: Sun, Ye, Koh, Hiromi W.L., Choi, Hyungwon, Koh, Woon-Puay, Yuan, Jian-Min, Newman, John W., Su, Jin, Fang, Jinling, Ong, Choon Nam, van Dam, Rob M.
Format: Article
Language:English
Subjects:
Aged
Aged, 80 and over
Arachidonic Acid - blood
Asian Continental Ancestry Group
Case-Control Studies
diet and dietary lipids
eicosanoids
epidemiology
fatty acid/metabolism
Female
heart
Humans
lipidomics
lipids
mass spectrometry
Middle Aged
Myocardial Infarction - blood
Myocardial Infarction - epidemiology
Myocardial Infarction - pathology
nutrition
oxidized lipids
Oxylipins - blood
Patient-Oriented and Epidemiological Research
Prospective Studies
Risk Factors
Singapore
Stearic Acids - blood
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Summary:We aimed to examine the prospective association between plasma FAs, oxylipins, and risk of acute myocardial infarction (AMI) in a Singapore Chinese population. A nested case-control study with 744 incident AMI cases and 744 matched controls aged 47–83 years was conducted within the Singapore Chinese Health Study. Nineteen plasma FAs and 12 oxylipins were quantified using MS. These were grouped into 12 FA clusters and 5 oxylipin clusters using hierarchical clustering, and their associations with AMI risk were assessed. Long-chain n-3 FAs [odds ratio (OR) = 0.67 per SD increase, 95% confidence interval (CI): 0.53–0.84, P < 0.001] and stearic acid (OR = 0.65, 95% CI: 0.44–0.97, P = 0.03) were inversely associated with AMI risk, whereas arachidonic acid (AA) was positively associated with AMI risk (OR = 1.25, 95% CI: 1.03–1.52, P = 0.02) in the multivariable model with adjustment for other FAs. Further adjustment for oxylipins did not substantially change these associations. An inverse association was observed between AA-derived oxylipin, thromboxane (TX)B2, and AMI risk (OR = 0.81, 95% CI: 0.71–0.93, P = 0.003). Circulating long-chain n-3 FAs and stearic acid were associated with a lower and AA was associated with a higher AMI risk in this Chinese population. The association between the oxylipin TXB2 and AMI requires further research.
ISSN:0022-2275
1539-7262
DOI:10.1194/jlr.P066423