Diagnostic Yield of Oral Swab Testing by TB-LAMP for Diagnosis of Pulmonary Tuberculosis

A prospective study was conducted to ascertain the accuracy of oral swab specimens collected in the early morning, spot and at night for detecting pulmonary tuberculosis (TB). We prospectively enrolled patients with symptoms suggestive of pulmonary TB in Beijing Chest Hospital. An early morning sput...

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Bibliographic Details
Published in:Infection and drug resistance 2021-01, Vol.14, p.89-95
Main Authors: Song, Yanhua, Ma, Yifeng, Liu, Rongmei, Shang, Yuanyuan, Ma, Liping, Huo, Fengmin, Li, Yunxu, Shu, Wei, Wang, Yufeng, Gao, Mengqiu, Pang, Yu
Format: Article
Language:English
Subjects:
Accuracy
china
Diagnosis
Laboratories
Microscopy
oral swab
Original Research
Pulmonary tuberculosis
Sputum
tb-lamp
Tuberculosis
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Summary:A prospective study was conducted to ascertain the accuracy of oral swab specimens collected in the early morning, spot and at night for detecting pulmonary tuberculosis (TB). We prospectively enrolled patients with symptoms suggestive of pulmonary TB in Beijing Chest Hospital. An early morning sputum specimen was collected from each patient for GeneXpert MTB/RIF (Xpert) and mycobacterial culture. In addition, three oral swabs were collected for TB-LAMP testing. With the combined results of three oral swab specimens, the proportion of (MTB)-positive cases achieved 40.6%, which was comparable to results for Xpert and MGIT ( =0.603). Using Xpert plus MGIT as reference, the sensitivity of OS-LAMP on a single specimen ranged from 32.6% on the night oral swab to 50.0% on the morning swab. The combination of three oral swab specimens correctly identified 38 MTB-positive cases, indicating an overall sensitivity of 82.6%, which was significantly higher than that of a single oral swab specimen (
ISSN:1178-6973
1178-6973
DOI:10.2147/IDR.S284157