Blood bacterial resistant investigation collaborative system (BRICS) report: a national surveillance in China from 2014 to 2019

• Published in: Antimicrobial resistance & infection control 2022-01, Vol.11 (1), p.17-17, Article 17
• Main Authors: Chen, Yunbo, Ji, Jinru, Ying, Chaoqun, Liu, Zhiying, Yang, Qing, Kong, Haishen, Xiao, Yonghong
• Format: Article
• Language: English
• Subjects: Analysis; Antibiotics; Antimicrobial agents; Bacteria; Bacterial; Bacterial pneumonia; Beta lactamases; Blood; Blood-Borne Infections - epidemiology; Blood-Borne Pathogens - isolation & purification; Bloodstream infection; China; China - epidemiology; Collaboration; Disease control; Drug resistance; Drug resistance in microorganisms; Drug Resistance, Bacterial; E coli; Epidemiological Monitoring; Epidemiology; Escherichia coli; GDP; Gross Domestic Product; Health aspects; Health surveillance; Hospitals; Humans; Imipenem; Investigations; Medical examination; Medical laboratories; Medical research; Medicine, Experimental; Methicillin; Mortality; National resistance surveillance; Organisms; Pathogens; Patients; Penicillin; Pneumonia; Prevalence; Public health; Resistance; Staphylococcus infections; Statistical analysis; Streptococcus infections; Trends
• ISSN: 2047-2994; 2047-2994
• DOI: 10.1186/s13756-022-01055-5

In this first national bloodstream infection (BSI) surveillance program in China, we assessed the composition of pathogenic bacteria and the trends for antimicrobial susceptibility over a 6-year period in China. Blood bacterial isolates from patients at hospitals participating in the Blood Bacterial Resistant Investigation Collaborative System (BRICS) were collected from January 2014 to December 2019. Only the first isolate of a species per patient was eligible over the full study period. Antibiotic-susceptibility testing was conducted by agar-dilution or broth-dilution methods as recommended by the Clinical and Laboratory Standards Institute (CLSI). WHONET 5.6 was used to analyze data. During the study period, 27,899 bacterial strains were collected. Gram-positive organisms accounted for 29.5% (8244) of the species identified and Gram-negative organisms accounted for 70.5% (19,655). The most-commonly isolated organisms in blood cultures were Escherichia coli, Klebsiella pneumoniae, Staphylococcus aureus, coagulase-negative Staphylococci, and Acinetobacter baumannii. The prevalence of multidrug-resistant organisms, such as E. coli, K. pneumoniae, A. baumannii was higher in tertiary hospitals, whereas extended-spectrum, β-lactamase-producing E. coli (ESBL-E. coli), carbapenem-resistant A. baumannii were more prevalent in economically-developing areas. The prevalence of methicillin-resistant S. aureus declined from 39.0% (73/187) in 2014 to 25.9% (230/889) in 2019 (p