Brain Connectivity Changes after Osteopathic Manipulative Treatment: A Randomized Manual Placebo-Controlled Trial

The effects of osteopathic manipulative treatment (OMT) on functional brain connectivity in healthy adults is missing in the literature. To make up for this lack, we applied advanced network analysis methods to analyze resting state functional magnetic resonance imaging (fMRI) data, after OMT and Pl...

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Bibliographic Details
Published in:Brain sciences 2020-12, Vol.10 (12), p.969
Main Authors: Tramontano, Marco, Cerritelli, Francesco, Piras, Federica, Spanò, Barbara, Tamburella, Federica, Piras, Fabrizio, Caltagirone, Carlo, Gili, Tommaso
Format: Article
Language:English
Subjects:
Amygdala
Asymptomatic
Brain architecture
Brain mapping
Brain research
Cognition & reasoning
fMRI
functional connectivity
Functional magnetic resonance imaging
Functional morphology
Intervention
Magnetic resonance imaging
Multivariate analysis
Neural networks
Neuroimaging
osteopathic manipulative treatment
Osteopathic medicine
Pain
placebo
Precentral gyrus
Questionnaires
somatic dysfunction
Temporal gyrus
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Summary:The effects of osteopathic manipulative treatment (OMT) on functional brain connectivity in healthy adults is missing in the literature. To make up for this lack, we applied advanced network analysis methods to analyze resting state functional magnetic resonance imaging (fMRI) data, after OMT and Placebo treatment (P) in 30 healthy asymptomatic young participants randomized into OMT and placebo groups (OMTg; Pg). fMRI brain activity measures, performed before (T0), immediately after (T1) and three days after (T2) OMT or P were used for inferring treatment effects on brain circuit functional organization. Repeated measures ANOVA and post-hoc analysis demonstrated that Right Precentral Gyrus (F (2, 32) = 5.995, < 0.005) was more influential over the information flow immediately after the OMT, while decreased betweenness centrality in Left Caudate (F (2, 32) = 6.496, < 0.005) was observable three days after. Clustering coefficient showed a distinct time-point and group effect. At T1, reduced neighborhood connectivity was observed after OMT in the Left Amygdala (L-Amyg) (F (2, 32) = 7.269, < 0.005) and Left Middle Temporal Gyrus (F (2, 32) = 6.452, < 0.005), whereas at T2 the L-Amyg and Vermis-III (F (2, 32) = 6.772, < 0.005) increased functional interactions. Data demonstrated functional connectivity re-arrangement after OMT.
ISSN:2076-3425
2076-3425
DOI:10.3390/brainsci10120969