A non-ACE2-blocking neutralizing antibody against Omicron-included SARS-CoV-2 variants

• Published in: Signal transduction and targeted therapy 2022-01, Vol.7 (1), p.23-23, Article 23
• Main Authors: Duan, Xiaomin, Shi, Rui, Liu, Pulan, Huang, Qingrui, Wang, Fengze, Chen, Xinyu, Feng, Hui, Huang, Weijin, Xiao, Junyu, Yan, Jinghua
• Format: Article
• Language: English
• Subjects: 631/250/255; 692/420/254; ACE2; Angiotensin-converting enzyme 2; Angiotensin-Converting Enzyme 2 - chemistry; Angiotensin-Converting Enzyme 2 - immunology; Angiotensin-Converting Enzyme 2 - metabolism; Animals; Antibodies, Monoclonal - chemistry; Antibodies, Monoclonal - immunology; Antibodies, Monoclonal - metabolism; Antibodies, Monoclonal - pharmacology; Antibodies, Viral - chemistry; Antibodies, Viral - immunology; Antibodies, Viral - metabolism; Antibodies, Viral - pharmacology; Binding Sites; Cancer Research; Cell Biology; Cell Line, Tumor; Chlorocebus aethiops; COVID-19 - drug therapy; COVID-19 - immunology; COVID-19 - virology; Cryoelectron Microscopy; Epitopes - chemistry; Epitopes - immunology; Epitopes - metabolism; Gene Expression; Hepatocytes - drug effects; Hepatocytes - immunology; Hepatocytes - virology; Humans; Internal Medicine; Letter; Medicine; Medicine & Public Health; Mice; Models, Molecular; Mutation; Oncology; Pathology; Protein Binding; Protein Conformation, beta-Strand; Protein Interaction Domains and Motifs; Receptors, Virus - chemistry; Receptors, Virus - immunology; Receptors, Virus - metabolism; SARS-CoV-2 - drug effects; SARS-CoV-2 - genetics; SARS-CoV-2 - immunology; Severe acute respiratory syndrome coronavirus 2; Spike Glycoprotein, Coronavirus - antagonists & inhibitors; Spike Glycoprotein, Coronavirus - chemistry; Spike Glycoprotein, Coronavirus - immunology; Spike Glycoprotein, Coronavirus - metabolism; Vero Cells
• ISSN: 2059-3635; 2095-9907; 2059-3635
• DOI: 10.1038/s41392-022-00879-2