Comprehensive Analysis of the E2F Transcription Factor Family in Human Lung Adenocarcinoma

Background: E2F transcription factors (E2Fs), code a family of pivotal transcription factors, have been identified as key regulators in tumor tumorigenesis. However, the function of E2F family in human lung adenocarcinoma (LUAD) have not been fully elucidated. Methods: Herein, The Cancer Genome Atla...

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Bibliographic Details
Published in:International journal of general medicine 2022-07, Vol.15, p.5973-5984
Main Authors: Wang, Qixun, Liu, Jinping, Cheang, Iokfai, Li, Jinghang, Chen, Tingzhen, Li, Yanxiu, Yu, Bo
Format: Article
Language:English
Subjects:
Adenocarcinoma
Algorithms
Antibodies
Cancer
Cancer therapies
Cell cycle
Chemokines
Comparative analysis
Cytokines
Dendritic cells
DNA binding proteins
e2f transcription factors
Family
Gene mutations
Genes
Genetic aspects
Genomics
immune cell infiltration
Immunotherapy
lung adenocarcinoma
Lung cancer
Medical prognosis
Mutation
Original Research
Prognosis
Survival analysis
T cells
tcga
Transcription factors
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Summary:Background: E2F transcription factors (E2Fs), code a family of pivotal transcription factors, have been identified as key regulators in tumor tumorigenesis. However, the function of E2F family in human lung adenocarcinoma (LUAD) have not been fully elucidated. Methods: Herein, The Cancer Genome Atlas (TCGA) databases, Kaplan-Meier plotter, cBioPortal and TIMER were used to analyze differential expression, prognostic value, genetic alteration and immune cell infiltration of E2Fs in LUAD patients. Results: The expression levels of E2Fs (E2F1-8) were all significantly upregulated in LUAD tissues compared with normal lung tissues. All eight E2Fs had low rates of gene mutation in LUAD patients from cBioPortal databases. Survival analysis revealed that E2F2 (P=0.038; HR 1.36; 95% CI 1.02-1.81), E2F7 (P
ISSN:1178-7074
1178-7074
DOI:10.2147/IJGM.S369582