miRNA-21 as a novel therapeutic target in lung cancer

Lung cancer is a leading cause of cancer death, and late diagnosis is one of the most important reasons for the high mortality rate. microRNAs (miRNAs) are key players in gene regulation and therefore in tumorigenesis. As far as lung carcinogenesis is concerned, miRNAs open novel fields in biomarker...

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Bibliographic Details
Published in:Lung cancer (Auckland) 2016-01, Vol.7 (Issue 1), p.19-27
Main Authors: Markou, Athina, Zavridou, Martha, Lianidou, Evi S
Format: Article
Language:English
Subjects:
Angiogenesis
Apoptosis
Biomarkers
Biosynthesis
Breast cancer
Cancer therapies
Care and treatment
Cell cycle
Chemotherapy
Diagnosis
Gene expression
Genetic aspects
Homeopathy
Lung cancer
Materia medica and therapeutics
Medical prognosis
Metastasis
MicroRNA
MicroRNAs
miR-21
Mutation
NSCLC
Plasma
Proteins
response to therapy
Review
Risk factors
RNA polymerase
therapeutic target
Therapeutics
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Summary:Lung cancer is a leading cause of cancer death, and late diagnosis is one of the most important reasons for the high mortality rate. microRNAs (miRNAs) are key players in gene regulation and therefore in tumorigenesis. As far as lung carcinogenesis is concerned, miRNAs open novel fields in biomarker research, in diagnosis, and in therapy. In this review we focus on miR-21 in lung cancer and especially on how miR-21 is involved 1) as a biomarker in response or resistance to therapy or 2) as a therapeutic target.
ISSN:1179-2728
1179-2728
DOI:10.2147/LCTT.S60341