Thy-1 as an Integrator of Diverse Extracellular Signals

Thy-1 was discovered over 50 years ago, and in that time investigators from a broad variety of fields have described numerous and heterogeneous biological functions of Thy-1 in multiple contexts. As an outwardly facing cell surface molecule, it is well positioned to receive extracellular signals; pr...

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Bibliographic Details
Published in:Frontiers in cell and developmental biology 2019-02, Vol.7, p.26-26
Main Author: Hagood, James S
Format: Article
Language:English
Subjects:
Cell and Developmental Biology
extracellular vesicles
mechanotransduction
signaling
stem cells
Thy-1
viral entry
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Summary:Thy-1 was discovered over 50 years ago, and in that time investigators from a broad variety of fields have described numerous and heterogeneous biological functions of Thy-1 in multiple contexts. As an outwardly facing cell surface molecule, it is well positioned to receive extracellular signals; previously reviewed studies have confirmed an important role in cell-cell and cell-matrix adhesion, cell migration, and regulation of outside-in signaling. More recent studies reviewed here expand the repertoire of Thy-1 effects on signaling pathways, and reveal novel roles in mechanotransduction, cellular differentiation, viral entry, and extracellular vesicle binding and internalization. All of these studies contribute to understanding Thy-1 as a context-dependent integrator of a diverse range of extracellular information, and provide impetus for further studies, some of which are suggested here.
ISSN:2296-634X
2296-634X
DOI:10.3389/fcell.2019.00026