Annexin levels in GCF determine the imbalance of periodontal inflammatory regulation

• Published in: Scientific reports 2024-11, Vol.14 (1), p.28833-10, Article 28833
• Main Authors: Yilmaz, Melis, Bal, İpek, Hanli, Sena, Turkmen, Emrah, Balci, Nur, Toygar, Hilal Uslu
• Format: Article
• Language: English
• Subjects: 692/420; 692/420/256; Adult; Annexin; Annexin A1 - blood; Annexin A1 - metabolism; Annexin A2 - metabolism; Biomarkers - blood; Biomarkers - metabolism; Case-Control Studies; Cytokine; Female; Gingival Crevicular Fluid - metabolism; Gum disease; Humanities and Social Sciences; Humans; IL-1β; Inflammation; Inflammation - metabolism; Interleukin-1beta - blood; Interleukin-1beta - metabolism; Male; Middle Aged; multidisciplinary; Periodontal diseases; Periodontitis; Periodontitis - blood; Periodontitis - metabolism; Saliva; Saliva - metabolism; Science; Science (multidisciplinary)
• ISSN: 2045-2322; 2045-2322
• DOI: 10.1038/s41598-024-80418-x

Objective: Annexin-1 (ANXA1), a member of the annexin family, plays a role in the resolution of inflammation and the regulation of anti-inflammatory responses, while annexin-2 (ANXA2) is involved in the initiation of the inflammatory responses. The aim of this study was to determine the effects of annexin family (ANXA1 and ANXA2) in periodontal disease. Methods: Healthy participants (n:25) and stage III, grade B periodontitis (n:25) patients enrolled for this study. Clinical periodontal parameters and the periodontal inflamed surface area (PISA) levels were noted. Serum, saliva, and gingival crevicular fluid (GCF) samples were collected to measure the ANXA1, ANXA2 and IL-1β levels. Results: Salivary and serum concentrations of ANXA1 was significantly lower in the periodontitis group than in the control group (respectively, p  = 0.0177 and p =