Microglia Modulate Neurodevelopment in Autism Spectrum Disorder and Schizophrenia

Neurodevelopmental disorders (NDDs) include various neurological disorders with high genetic heterogeneity, characterized by delayed or impaired cognition, communication, adaptive behavior, and psychomotor skills. These disorders result in significant morbidity for children, thus burdening families...

Full description

Saved in:
Bibliographic Details
Published in:International journal of molecular sciences 2023-12, Vol.24 (24), p.17297
Main Authors: Fan, Guangxiang, Ma, Jiamin, Ma, Ruyi, Suo, Mingjiao, Chen, Yiwen, Zhang, Siming, Zeng, Yan, Chen, Yushan
Format: Article
Language:English
Subjects:
Apoptosis
Autism
Autism Spectrum Disorder
autism spectrum disorder (ASD)
Bone marrow
Brain
Cell death
Child
Cytokines
Growth factors
Humans
Immune system
Kinases
microglia
Microglia - physiology
Morphology
neurodevelopment
Neurogenesis
Neurons
Neurotoxicity
Physiology
Proteins
Schizophrenia
schizophrenia (SZ)
synapse development
Transcription factors
Tumor necrosis factor-TNF
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Neurodevelopmental disorders (NDDs) include various neurological disorders with high genetic heterogeneity, characterized by delayed or impaired cognition, communication, adaptive behavior, and psychomotor skills. These disorders result in significant morbidity for children, thus burdening families and healthcare/educational systems. However, there is a lack of early diagnosis and effective therapies. Therefore, a more connected approach is required to explore these disorders. Microglia, the primary phagocytic cells within the central nervous system, are crucial in regulating neuronal viability, influencing synaptic dynamics, and determining neurodevelopmental outcomes. Although the neurobiological basis of autism spectrum disorder (ASD) and schizophrenia (SZ) has attracted attention in recent decades, the role of microglia in ASD and SZ remains unclear and requires further discussion. In this review, the important and frequently multifaceted roles that microglia play during neurodevelopment are meticulously emphasized and potential microglial mechanisms that might be involved in conditions such as ASD and SZ are postulated. It is of utmost importance to acquire a comprehensive understanding of the complexities of the interplay between microglia and neurons to design effective, targeted therapeutic strategies to mitigate the effects of NDDs.
ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms242417297