Carotid artery plaque uptake of 11C-PK11195 inversely correlates with circulating monocytes and classical CD14++CD16− monocytes expressing HLA-DR

We explored the relation between blood concentrations of monocyte/lymphocyte subsets and carotid artery plaque macrophage content, measured by positron emission tomography (PET) with 11C-PK11195. In 9 patients with carotid plaques we performed 11C-PK11195-PET/computed tomography angiography imaging...

Full description

Saved in:
Bibliographic Details
Published in:International journal of cardiology. Heart & vasculature 2018-12, Vol.21, p.32-35
Main Authors: Ammirati, Enrico, Moroni, Francesco, Magnoni, Marco, Busnardo, Elena, Di Terlizzi, Simona, Villa, Chiara, Sizzano, Federico, Scotti, Isabella, Palini, Alessio, Presotto, Luca, Bettinardi, Valentino, Spagnolo, Pietro, Besana, Francesca, Gianolli, Luigi, Rimoldi, Ornella E., Camici, Paolo G.
Format: Article
Language:English
Subjects:
11C-PK11195 uptake
Atherosclerosis
Carotid plaque
Classical monocytes
Original Paper
Positron emission tomography
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:We explored the relation between blood concentrations of monocyte/lymphocyte subsets and carotid artery plaque macrophage content, measured by positron emission tomography (PET) with 11C-PK11195. In 9 patients with carotid plaques we performed 11C-PK11195-PET/computed tomography angiography imaging and measurement of absolute concentrations and frequencies of circulating monocytes and T-cell subsets. Plaque standardized uptake value (SUV) for 11C-PK11195 was negatively correlated with concentrations of total monocytes (r = −0.58, p = 0.05) and CD14++CD16−HLA-DR+ classical subset (r = −0.82, p = 0.005). These correlations hold true also in relation to plaque target to background ratio. No correlation was observed between plaque SUV and CD3+T lymphocytes, CD4+T lymphocytes nor with activated CD3+CD4+T cells expressing HLA-DR. We first demonstrated a reduction in the absolute concentration of monocytes and particularly in classical monocytes expressing HLA-DR in the presence of an increased uptake of 11C-PK11195 in carotid plaques. The present work, despite being a pilot study comprising only a small number of subjects provides new insights in the search for specific cellular biomarkers with potential diagnostic and prognostic value in patients with a known carotid plaque.
ISSN:2352-9067
2352-9067
DOI:10.1016/j.ijcha.2018.09.005