microRNA-128-3p inhibits proliferation and accelerates apoptosis of gastric cancer cells via inhibition of TUFT1

Gastric cancer (GC) is a malignant tumor rooting in the gastric mucosal epithelium, ranking the first among various malignant tumors. Therefore, the influence of microRNA-128-3p (miR-128-3p) by regulation of Tuftelin1 (TUFT1) on GC cells was investigated. The expression levels of miR-128-3p and TUFT...

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Bibliographic Details
Published in:World journal of surgical oncology 2023-02, Vol.21 (1), p.47-47, Article 47
Main Authors: Du, Xiong, Li, Yanxin, Lian, Bin, Yin, Xiangli
Format: Article
Language:English
Subjects:
Analysis
Antibodies
Apoptosis
Binding sites
Bioinformatics
Cancer
Cancer therapies
Care and treatment
Cell Line, Tumor
Cell Movement
Cell Proliferation
Diagnosis
Epithelial-Mesenchymal Transition
Epithelium
Gastric cancer
Gastric mucosa
Gene Expression Regulation, Neoplastic
Health aspects
Humans
Invasion
Medical prognosis
Mesenchyme
Metastasis
MicroRNA
MicroRNA-128-3p
MicroRNAs
MicroRNAs - genetics
MicroRNAs - metabolism
miRNA
Oligonucleotides
Plasmids
Proliferation
Proteins
Reagents
Ribonucleic acid
RNA
Software
Statistical analysis
Stomach cancer
Stomach Neoplasms - pathology
Survival
Tuftelin1
Tumors
Variance analysis
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Summary:Gastric cancer (GC) is a malignant tumor rooting in the gastric mucosal epithelium, ranking the first among various malignant tumors. Therefore, the influence of microRNA-128-3p (miR-128-3p) by regulation of Tuftelin1 (TUFT1) on GC cells was investigated. The expression levels of miR-128-3p and TUFT1 in GC tissues and cells were detected. The correlation between miR-128-3p expression and overall survival of GC patients was analyzed. Human GC cells MGC803 were transfected with miR-128-3p or TUFT1-related oligonucleotides to figure their roles in viability, apoptosis, invasion, as well as epithelial-mesenchymal transition (EMT). The relationship between miR-128-3p and TUFT1 was validated. miR-128-3p expression was low and TUFT1 expression was high in GC tissues. miR-128-3p expression was positively correlated with the overall survival of patients with GC. miR-128-3p targeted TUFT1. Up-regulated miR-128-3p or suppressed TUFT1 repressed viability, invasion, and EMT, and accelerated apoptosis of GC cells. Overexpressed TUFT1 reduced miR-128-3p-mediated growth inhibition of GC cells. The study stresses that miR-128-3p can inhibit TUFT1 expression, thereby repressing GC cell activities.
ISSN:1477-7819
1477-7819
DOI:10.1186/s12957-023-02906-0