Redox Regulation of Mitochondrial Potassium Channels Activity

Redox reactions exert a profound influence on numerous cellular functions with mitochondria playing a central role in orchestrating these processes. This pivotal involvement arises from three primary factors: (1) the synthesis of reactive oxygen species (ROS) by mitochondria, (2) the presence of a s...

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Bibliographic Details
Published in:Antioxidants 2024-04, Vol.13 (4), p.434
Main Authors: Lewandowska, Joanna, Kalenik, Barbara, Wrzosek, Antoni, Szewczyk, Adam
Format: Article
Language:English
Subjects:
Calcium channels
Calcium channels (voltage-gated)
Calcium conductance
Electron transport
Enzymes
Heart
Homeostasis
Hypoxia
Inflammation
Injuries
Ischemia
ischemia/reperfusion injury
Metabolism
Mitochondria
mitochondrial potassium channel
Oxidation
Oxidative stress
Permeability
Physiology
Potassium
Potassium channels
Potassium channels (voltage-gated)
Proteins
Reactive oxygen species
redox
Redox properties
Redox reactions
Reperfusion
Respiration
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Summary:Redox reactions exert a profound influence on numerous cellular functions with mitochondria playing a central role in orchestrating these processes. This pivotal involvement arises from three primary factors: (1) the synthesis of reactive oxygen species (ROS) by mitochondria, (2) the presence of a substantial array of redox enzymes such as respiratory chain, and (3) the responsiveness of mitochondria to the cellular redox state. Within the inner mitochondrial membrane, a group of potassium channels, including ATP-regulated, large conductance calcium-activated, and voltage-regulated channels, is present. These channels play a crucial role in conditions such as cytoprotection, ischemia/reperfusion injury, and inflammation. Notably, the activity of mitochondrial potassium channels is intricately governed by redox reactions. Furthermore, the regulatory influence extends to other proteins, such as kinases, which undergo redox modifications. This review aims to offer a comprehensive exploration of the modulation of mitochondrial potassium channels through diverse redox reactions with a specific focus on the involvement of ROS.
ISSN:2076-3921
2076-3921
DOI:10.3390/antiox13040434