Serum Lipid Profiles of Patients Taking Efavirenz-Based Antiretroviral Regimen Compared to Ritonavir-Boosted Atazanavir with an Optimized Background at Zewditu Memorial Hospital, Addis Ababa, Ethiopia

Dyslipidemia represents significant health care concerns in patients taking antiretroviral therapy due to their association with cardiovascular disease risk. There is limited data regarding the effects of boosted atazanavir (ATV/r) treatment in the lipid profiles of Ethiopian HIV patients. Thus, thi...

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Bibliographic Details
Published in:HIV/AIDS (Auckland) 2021-01, Vol.13, p.217-227
Main Authors: Muche Belete, Abebe, Seifu, Daniel, Menon, Menakath, Amogne, Wondwossen, Shewa, Aster, Adela Tefera, Alemu
Format: Article
Language:English
Subjects:
Acquired immune deficiency syndrome
Adults
AIDS
Analysis
Analysis and chemistry
Anti-HIV agents
Antiretroviral drugs
Antiretroviral therapy
Antiviral agents
Antiviral drugs
Atazanavir
Blood
Body mass index
Cardiovascular diseases
Care and treatment
CD4 antigen
Cholesterol
Diabetes
Dyslipidemia
Efavirenz
High density lipoprotein
Highly active antiretroviral therapy
HIV
HIV patients
Human immunodeficiency virus
Laboratories
Lamivudine
Lipids
Low density lipoprotein
Low density lipoproteins
Medical research
Medicine, Experimental
Metabolic disorders
Metabolism
Morbidity
Original Research
Patients
Population
Ratios
Reverse transcriptase inhibitors
Ritonavir
ritonavir-boosted atazanavir
Sample size
Software
Tenofovir
Thyroid gland
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Summary:Dyslipidemia represents significant health care concerns in patients taking antiretroviral therapy due to their association with cardiovascular disease risk. There is limited data regarding the effects of boosted atazanavir (ATV/r) treatment in the lipid profiles of Ethiopian HIV patients. Thus, this study compares the mean values of lipid profile differences of HIV patients on ATV/r-based regimen compared to efavirenz (EFV)-based regimen, while the background is Tenofovir Disoproxil Fumarate/lamivudine. A comparative hospital-based cross-sectional study was conducted among adult HIV-infected patients at Zewditu Memorial Hospital, Addis Ababa, Ethiopia, from July-September 2017. An equal number of EFV and ATV/r-treated patients (n=90 each) receiving for 1-year and over were included in the study. Serum total cholesterol (TC), triglyceride (TG), gigh-density lipoprotein cholesterol (HDL-c), and low-density lipoprotein cholesterol (LDL-c) were measured. Data comparison used chi-square test, Student's -test and Mann-Whitney -test. Multivariate logistic regression analysis and -value
ISSN:1179-1373
1179-1373
DOI:10.2147/HIV.S296170