Phylogeographical Analyses and Antibiotic Resistance Genes of Acinetobacter johnsonii Highlight Its Clinical Relevance

Acinetobacter johnsonii has been severely understudied and its population structure and the presence of antibiotic resistance genes (ARGs) are very much uncertain. Our phylogeographical analysis shows that intercontinental transmission has occurred frequently and that different lineages are circulat...

Full description

Saved in:
Bibliographic Details
Published in:mSphere 2020-07, Vol.5 (4)
Main Authors: Castillo-Ramírez, Santiago, Mateo-Estrada, Valeria, Gonzalez-Rocha, Gerardo, Opazo-Capurro, Andrés
Format: Article
Language:English
Subjects:
Acinetobacter
Acinetobacter johnsonii
Antibiotic resistance
Antibiotics
Clinical Science and Epidemiology
Drug resistance
emerging pathogens
Gene transfer
Genes
Genomes
Genomics
horizontal gene transfer
Horizontal transfer
Mutation
Observation
Population
population genomics
Population structure
Recombination
Single-nucleotide polymorphism
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Acinetobacter johnsonii has been severely understudied and its population structure and the presence of antibiotic resistance genes (ARGs) are very much uncertain. Our phylogeographical analysis shows that intercontinental transmission has occurred frequently and that different lineages are circulating within single countries; notably, clinical and nonclinical strains are not well differentiated from one another. Importantly, in this species recombination is a significant source of single nucleotide polymorphisms. Furthermore, our results show this species could be an important reservoir of ARGs since it has a significant amount of ARGs, and many of them show signals of horizontal gene transfer. Thus, this study clearly points out the clinical importance of A. johnsonii and the urgent need to better appreciate its genomic diversity.
ISSN:2379-5042
2379-5042
DOI:10.1128/mSphere.00581-20