Spatial Resolution of a small animal PET scanner using 68Ga isotope

Nuclear Medicine is a modality that has been growing a lot in Brazil and in the world, bringing new radiopharmaceuticals and technologies for the diagnosis and treatment of diseases, making them more effective and accurate. In the development of new radiopharmaceuticals for use in positron emission...

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Bibliographic Details
Published in:Brazilian Journal of Radiation Sciences 2024-04, Vol.12 (2), p.e2404
Main Authors: Garcia, Victoria M., Silva, A. C. M., Gontijo, Rodrigo Modesto Gadelha, Vidal Ferreira, Andréa
Format: Article
Language:English
Subjects:
68Ga
PET
Positron Emission Tomography
Quality Control
Spatial resolution
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Summary:Nuclear Medicine is a modality that has been growing a lot in Brazil and in the world, bringing new radiopharmaceuticals and technologies for the diagnosis and treatment of diseases, making them more effective and accurate. In the development of new radiopharmaceuticals for use in positron emission tomography (PET), the preclinical studies step largely uses PET scanners dedicated to small animals. To achieve this, quality control tests must be carried out to ensure the efficiency of the equipment. Thus, this work aimed to evaluate the spatial resolution of the small animals PET scanner of the CDTN using the isotope 68Ga. In this sense, a microPET hot rod phantom and a commercial 68Ge/68Ga generator were used to obtain PET images. The analysis of the 68Ga-PET images of the simulator was carried out qualitatively and quantitatively and revealed that the spatial resolution of the system using the 68Ga is 3.5 mm. A Medicina Nuclear é uma modalidade que vem crescendo muito no Brasil e no mundo, trazendo novos radiofármacos e tecnologias para o diagnóstico e tratamento de doenças, tornando-os mais eficazes e precisos. No desenvolvimento de novos radiofármacos para uso em tomografia por emissão de pósitrons (PET), a etapa de estudos pré-clínicos utiliza amplamente tomógafos PET dedicados a pequenos animais. Para isso, devem ser realizados testes de controle de qualidade para garantir a eficiência do equipamento. Assim, este trabalho teve como objetivo avaliar a resolução espacial do tomógrafo PET de pequenos animais do CDTN utilizando o isótopo 68Ga. Nesse sentido, um simulador hot rod microPET e um gerador comercial 68Ge/68Ga foram utilizados para obtenção de imagens PET. A análise das imagens 68Ga-PET do simulador foi realizada qualitativa e quantitativamente e revelou que a resolução espacial do sistema utilizando o 68Ga é de 3,5 mm. 
ISSN:2319-0612
2319-0612
DOI:10.15392/2319-0612.2024.2404