Can Artemisia herba-alba Be Useful for Managing COVID-19 and Comorbidities?

• Published in: Molecules (Basel, Switzerland) Switzerland), 2022-01, Vol.27 (2), p.492
• Main Authors: Hasan, Anamul, Biswas, Partha, Bondhon, Tohmina Afroze, Jannat, Khoshnur, Paul, Tridib K, Paul, Alok K, Jahan, Rownak, Nissapatorn, Veeranoot, Mahboob, Tooba, Wilairatana, Polrat, Hasan, Md Nazmul, de Lourdes Pereira, Maria, Wiart, Christophe, Rahmatullah, Mohammed
• Format: Article
• Language: English
• Subjects: Artemisia - chemistry; Artemisia herba-alba; Caffeoylquinic acid; Cancer therapies; Chinese medicine; Clinical trials; Comorbidity; Coronavirus 3C Proteases - chemistry; Coronaviruses; COVID-19; COVID-19 - epidemiology; COVID-19 Drug Treatment; COVID-19 vaccines; Developing countries; Diabetes; Drug dosages; Ethnobotany - methods; FDA approval; Herbal medicine; Hypertension; Infections; Kidney diseases; LDCs; Ligands; Malaria; Medicinal plants; Molecular docking; Molecular Docking Simulation; Molecular dynamics; Molecular Dynamics Simulation; Older people; Pandemics; Patients; Pharmacology; Phytochemicals; Phytochemicals - chemistry; Plant Extracts - chemistry; Plant Extracts - pharmacology; Plants, Medicinal - chemistry; Rutin; Severe acute respiratory syndrome coronavirus 2; Signs and symptoms; Toxicity
• ISSN: 1420-3049; 1420-3049
• DOI: 10.3390/molecules27020492

The focus of this roadmap is to evaluate the possible efficacy of Asso. (Asteraceae) for the treatment of COVID-19 and some of its symptoms and several comorbidities using a combination of in silico (molecular docking) studies, reported ethnic uses, and pharmacological activity studies of this plant. In this exploratory study, we show that various phytochemicals from can be useful against COVID-19 (in silico studies) and for its associated comorbidities. COVID-19 is a new disease, so reports of any therapeutic treatments against it (traditional or conventional) are scanty. On the other hand, we demonstrate, using as an example, that through a proper search and identification of medicinal plant(s) and their phytochemicals identification using secondary data (published reports) on the plant's ethnic uses, phytochemical constituents, and pharmacological activities against COVID-19 comorbidities and symptoms coupled with the use of primary data obtained from in silico (molecular docking and molecular dynamics) studies on the binding of the selected plant's phytochemicals (such as: rutin, 4,5-di- -caffeoylquinic acid, and schaftoside) with various vital components of SARS-CoV-2, it may be possible to rapidly identify plants that are suitable for further research regarding therapeutic use against COVID-19 and its associated symptoms and comorbidities.