Temperature/pH-Sensitive Double Cross-Linked Hydrogels as Platform for Controlled Delivery of Metoclopramide

Novel double cross-linked (DC) hydrogels with pH-/temperature-sensitive properties were designed and developed. Therefore, linear pH-sensitive poly(methyl vinyl ether-alt-maleic acid) (P(VME/MA)) macromolecules were absorbed within a thermosensitive poly( -isopropylacrylamide-co-hydroxyethylacrylami...

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Bibliographic Details
Published in:Gels 2022-12, Vol.8 (12), p.824
Main Authors: Coșman, Bogdan-Paul, Bucătariu, Sanda-Maria, Constantin, Marieta, Fundueanu, Gheorghe
Format: Article
Language:English
Subjects:
Biocompatibility
Biomedical materials
Central nervous system depressants
Comparative analysis
Crosslinking
double cross-linked
drug delivery systems
Enzymes
Hydrogels
Infrared spectroscopy
Isopropylacrylamide
Macromolecules
Maleic acid
Mechanical properties
Mechanical tests
Metoclopramide
Moisture content
Polymers
smart hydrogels
Solvents
Swelling
Tissue engineering
Vinyl ethers
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Summary:Novel double cross-linked (DC) hydrogels with pH-/temperature-sensitive properties were designed and developed. Therefore, linear pH-sensitive poly(methyl vinyl ether-alt-maleic acid) (P(VME/MA)) macromolecules were absorbed within a thermosensitive poly( -isopropylacrylamide-co-hydroxyethylacrylamide)-hydrogel (PNH) and, subsequently, cross-linked together through a solvent-free thermal method. As a novelty, double cross-linked hydrogels were obtained from previously purified polymers in the absence of any solvent or cross-linking agent, which are generally harmful for the body. The new DC structures were characterized by FT-IR spectroscopy, SEM, swelling kinetic measurements, and mechanical tests. The resulting scaffolds exhibited interconnected pores and a flexible pattern, compared to the brittle structure of conventional PNH. The swelling kinetics of DC hydrogels were deeply affected by temperature (25 and 37 °C) and pH (7.4 and 1.2). Furthermore, the hydrogels absorbed a great amount of water in a basic environment and displayed improved mechanical properties. Metoclopramide (Met) was loaded within DC hydrogels as a model drug to investigate the ability of the support to control the drug release rate. The results obtained recommended them as convenient platforms for the oral administration of drugs, with the release of the largest part of the active principle occurring in the colon.
ISSN:2310-2861
2310-2861
DOI:10.3390/gels8120824