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Hypertension linked to Alzheimer’s disease via stroke: Mendelian randomization
This study aimed to investigate the relationship between hypertension and Alzheimer’s disease (AD) and demonstrate the key role of stroke in this relationship using mediating Mendelian randomization. AD, a neurodegenerative disease characterized by memory loss, cognitive impairment, and behavioral a...
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Published in: | Scientific reports 2023-12, Vol.13 (1), p.21606-21606, Article 21606 |
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description | This study aimed to investigate the relationship between hypertension and Alzheimer’s disease (AD) and demonstrate the key role of stroke in this relationship using mediating Mendelian randomization. AD, a neurodegenerative disease characterized by memory loss, cognitive impairment, and behavioral abnormalities, severely affects the quality of life of patients. Hypertension is an important risk factor for AD. However, the precise mechanism underlying this relationship is unclear. To investigate the relationship between hypertension and AD, we used a mediated Mendelian randomization method and screened for mediating variables between hypertension and AD by setting instrumental variables. The results of the mediated analysis showed that stroke, as a mediating variable, plays an important role in the causal relationship between hypertension and AD. Specifically, the mediated indirect effect value for stroke obtained using multivariate mediated MR analysis was 54.9%. This implies that approximately 55% of the risk of AD owing to hypertension can be attributed to stroke. The results suggest that the increased risk of AD owing to hypertension is mediated through stroke. The finding not only sheds light on the relationship between hypertension and AD but also indicates novel methods for the prevention and treatment of AD. By identifying the critical role of stroke in the link between hypertension and AD, this study provides insights into potential interventions that could mitigate the impact of hypertension on AD. This could help develop personalized treatments and help improve the quality of life of patients with AD who suffer from hypertension. |
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AD, a neurodegenerative disease characterized by memory loss, cognitive impairment, and behavioral abnormalities, severely affects the quality of life of patients. Hypertension is an important risk factor for AD. However, the precise mechanism underlying this relationship is unclear. To investigate the relationship between hypertension and AD, we used a mediated Mendelian randomization method and screened for mediating variables between hypertension and AD by setting instrumental variables. The results of the mediated analysis showed that stroke, as a mediating variable, plays an important role in the causal relationship between hypertension and AD. Specifically, the mediated indirect effect value for stroke obtained using multivariate mediated MR analysis was 54.9%. This implies that approximately 55% of the risk of AD owing to hypertension can be attributed to stroke. The results suggest that the increased risk of AD owing to hypertension is mediated through stroke. The finding not only sheds light on the relationship between hypertension and AD but also indicates novel methods for the prevention and treatment of AD. By identifying the critical role of stroke in the link between hypertension and AD, this study provides insights into potential interventions that could mitigate the impact of hypertension on AD. This could help develop personalized treatments and help improve the quality of life of patients with AD who suffer from hypertension.</description><identifier>ISSN: 2045-2322</identifier><identifier>EISSN: 2045-2322</identifier><identifier>DOI: 10.1038/s41598-023-49087-0</identifier><identifier>PMID: 38062190</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>631/378/2612 ; 631/378/2649 ; Alzheimer Disease - complications ; Alzheimer Disease - genetics ; Alzheimer's disease ; Cognitive ability ; Genome-Wide Association Study ; Humanities and Social Sciences ; Humans ; Hypertension ; Hypertension - complications ; Hypertension - genetics ; Mendelian Randomization Analysis ; multidisciplinary ; Neurodegenerative Diseases ; Polymorphism, Single Nucleotide ; Quality of Life ; Risk factors ; Science ; Science (multidisciplinary) ; Stroke ; Stroke - complications ; Stroke - genetics</subject><ispartof>Scientific reports, 2023-12, Vol.13 (1), p.21606-21606, Article 21606</ispartof><rights>The Author(s) 2023</rights><rights>2023. The Author(s).</rights><rights>The Author(s) 2023. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c436t-6026c4978610c99196c027514a28c5d68013506432f7ae9700be5296e2367d113</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.proquest.com/docview/2899188733/fulltextPDF?pq-origsite=primo$$EPDF$$P50$$Gproquest$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/2899188733?pq-origsite=primo$$EHTML$$P50$$Gproquest$$Hfree_for_read</linktohtml><link.rule.ids>314,780,784,25753,27924,27925,37012,37013,44590,75126</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38062190$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Tang, Chao</creatorcontrib><creatorcontrib>Ma, Yayu</creatorcontrib><creatorcontrib>Lei, Xiaoyang</creatorcontrib><creatorcontrib>Ding, Yaqi</creatorcontrib><creatorcontrib>Yang, Sushuang</creatorcontrib><creatorcontrib>He, Dian</creatorcontrib><title>Hypertension linked to Alzheimer’s disease via stroke: Mendelian randomization</title><title>Scientific reports</title><addtitle>Sci Rep</addtitle><addtitle>Sci Rep</addtitle><description>This study aimed to investigate the relationship between hypertension and Alzheimer’s disease (AD) and demonstrate the key role of stroke in this relationship using mediating Mendelian randomization. AD, a neurodegenerative disease characterized by memory loss, cognitive impairment, and behavioral abnormalities, severely affects the quality of life of patients. Hypertension is an important risk factor for AD. However, the precise mechanism underlying this relationship is unclear. To investigate the relationship between hypertension and AD, we used a mediated Mendelian randomization method and screened for mediating variables between hypertension and AD by setting instrumental variables. The results of the mediated analysis showed that stroke, as a mediating variable, plays an important role in the causal relationship between hypertension and AD. Specifically, the mediated indirect effect value for stroke obtained using multivariate mediated MR analysis was 54.9%. This implies that approximately 55% of the risk of AD owing to hypertension can be attributed to stroke. The results suggest that the increased risk of AD owing to hypertension is mediated through stroke. The finding not only sheds light on the relationship between hypertension and AD but also indicates novel methods for the prevention and treatment of AD. By identifying the critical role of stroke in the link between hypertension and AD, this study provides insights into potential interventions that could mitigate the impact of hypertension on AD. This could help develop personalized treatments and help improve the quality of life of patients with AD who suffer from hypertension.</description><subject>631/378/2612</subject><subject>631/378/2649</subject><subject>Alzheimer Disease - complications</subject><subject>Alzheimer Disease - genetics</subject><subject>Alzheimer's disease</subject><subject>Cognitive ability</subject><subject>Genome-Wide Association Study</subject><subject>Humanities and Social Sciences</subject><subject>Humans</subject><subject>Hypertension</subject><subject>Hypertension - complications</subject><subject>Hypertension - genetics</subject><subject>Mendelian Randomization Analysis</subject><subject>multidisciplinary</subject><subject>Neurodegenerative Diseases</subject><subject>Polymorphism, Single Nucleotide</subject><subject>Quality of Life</subject><subject>Risk factors</subject><subject>Science</subject><subject>Science (multidisciplinary)</subject><subject>Stroke</subject><subject>Stroke - complications</subject><subject>Stroke - genetics</subject><issn>2045-2322</issn><issn>2045-2322</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2023</creationdate><recordtype>article</recordtype><sourceid>PIMPY</sourceid><sourceid>DOA</sourceid><recordid>eNp9kc1uFiEUhonR2Kb2BlyYSdy4GT38DD_umkZtkza60DVhmDOVrzPwCfOZtCtvw9vzSqSd2hoXsoHAw8M5vIQ8p_CaAtdviqCd0S0w3goDWrXwiOwzEF3LOGOP_1rvkcNSNlBHx4yg5inZ4xokowb2yaeTqy3mBWMJKTZTiJc4NEtqjqbrrxhmzL9-_CzNEAq6gs334Jqy5HSJb5tzjANOwcUmuzikOVy7pTqekSejmwoe3s0H5Mv7d5-PT9qzjx9Oj4_OWi-4XFoJTHphlJYUvDHUSA9MdVQ4pn03SA2UdyAFZ6NyaBRAj7V8iYxLNVDKD8jp6h2S29htDrPLVza5YG83Ur6wLi_BT2jNaDqtRu-ol4Jx32vQzng99rwHBa66Xq2ubU7fdlgWO4ficZpcxLQrlhmoP9dpwSv68h90k3Y51k4t07UPrRW_odhK-ZxKyTjeF0jB3sRn1_hsjc_exmehXnpxp971Mw73V_6EVQG-AqUexQvMD2__R_sb4e-jUA</recordid><startdate>20231207</startdate><enddate>20231207</enddate><creator>Tang, Chao</creator><creator>Ma, Yayu</creator><creator>Lei, Xiaoyang</creator><creator>Ding, Yaqi</creator><creator>Yang, Sushuang</creator><creator>He, Dian</creator><general>Nature Publishing Group UK</general><general>Nature Publishing Group</general><general>Nature Portfolio</general><scope>C6C</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88A</scope><scope>88E</scope><scope>88I</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M2P</scope><scope>M7P</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>7X8</scope><scope>DOA</scope></search><sort><creationdate>20231207</creationdate><title>Hypertension linked to Alzheimer’s disease via stroke: Mendelian randomization</title><author>Tang, Chao ; 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AD, a neurodegenerative disease characterized by memory loss, cognitive impairment, and behavioral abnormalities, severely affects the quality of life of patients. Hypertension is an important risk factor for AD. However, the precise mechanism underlying this relationship is unclear. To investigate the relationship between hypertension and AD, we used a mediated Mendelian randomization method and screened for mediating variables between hypertension and AD by setting instrumental variables. The results of the mediated analysis showed that stroke, as a mediating variable, plays an important role in the causal relationship between hypertension and AD. Specifically, the mediated indirect effect value for stroke obtained using multivariate mediated MR analysis was 54.9%. This implies that approximately 55% of the risk of AD owing to hypertension can be attributed to stroke. The results suggest that the increased risk of AD owing to hypertension is mediated through stroke. The finding not only sheds light on the relationship between hypertension and AD but also indicates novel methods for the prevention and treatment of AD. By identifying the critical role of stroke in the link between hypertension and AD, this study provides insights into potential interventions that could mitigate the impact of hypertension on AD. This could help develop personalized treatments and help improve the quality of life of patients with AD who suffer from hypertension.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>38062190</pmid><doi>10.1038/s41598-023-49087-0</doi><tpages>1</tpages><oa>free_for_read</oa></addata></record> |
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subjects | 631/378/2612 631/378/2649 Alzheimer Disease - complications Alzheimer Disease - genetics Alzheimer's disease Cognitive ability Genome-Wide Association Study Humanities and Social Sciences Humans Hypertension Hypertension - complications Hypertension - genetics Mendelian Randomization Analysis multidisciplinary Neurodegenerative Diseases Polymorphism, Single Nucleotide Quality of Life Risk factors Science Science (multidisciplinary) Stroke Stroke - complications Stroke - genetics |
title | Hypertension linked to Alzheimer’s disease via stroke: Mendelian randomization |
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