Recent advances in cohesin biology

Sister chromatids are tethered together from the time they are formed in S-phase until they separate at anaphase. A protein complex called cohesin is responsible for holding the sister chromatids together and serves important roles in chromosome condensation, gene regulation, and the repair of DNA d...

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Bibliographic Details
Published in:F1000 research 2016, Vol.5, p.1909
Main Authors: Rankin, Susannah, Dawson, Dean S
Format: Article
Language:English
Subjects:
Biomacromolecule-Ligand Interactions
Cell Growth & Division
Protein Chemistry & Proteomics
Protein Folding
Review
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Summary:Sister chromatids are tethered together from the time they are formed in S-phase until they separate at anaphase. A protein complex called cohesin is responsible for holding the sister chromatids together and serves important roles in chromosome condensation, gene regulation, and the repair of DNA damage. Cohesin contains an open central pore and becomes topologically engaged with its DNA substrates. Entrapped DNA can be released either by the opening of a gate in the cohesin ring or by proteolytic cleavage of a component of the ring. This review summarizes recent research that provides important new insights into how DNA enters and exits the cohesin ring and how the rings behave on entrapped DNA molecules to provide functional cohesion.
ISSN:2046-1402
2046-1402
DOI:10.12688/f1000research.8881.1