Exosomal non-coding RNAs have a significant effect on tumor metastasis

Exosomes are produced by the majority of eukaryotic cells and are capable of transporting a variety of substances, including non-coding RNAs, between cells. Metastasis is a significant cause of death from cancer. Numerous studies have established an important role for exosomal non-coding RNAs in tum...

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Bibliographic Details
Published in:Molecular therapy. Nucleic acids 2022-09, Vol.29, p.16-35
Main Authors: Wang, Di, Zhang, Wei, Zhang, Chunxi, Wang, Liwei, Chen, Heng, Xu, Jianbin
Format: Article
Language:English
Subjects:
angiogenesis
EMT
exosome
immunity
lymphangiogenesis
microenvironment
MT: Non-coding RNAs
non-coding RNA
premetastatic niche
Review
tumor metastasis
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Summary:Exosomes are produced by the majority of eukaryotic cells and are capable of transporting a variety of substances, including non-coding RNAs, between cells. Metastasis is a significant cause of death from cancer. Numerous studies have established an important role for exosomal non-coding RNAs in tumor metastasis. Exosomal non-coding RNAs from a variety of cells have been shown to affect tumor metastasis via several mechanisms. Exosomes transmit non-coding RNAs between tumor cells, fibroblasts, endothelial cells, and immune cells within the tumor microenvironment. Exosomal non-coding RNAs also have an effect on epithelial-mesenchymal transition, angiogenesis, and lymphangiogenesis. Exosomes derived from tumor cells have the ability to transport non-coding RNAs to distant organs, thereby facilitating the formation of the metastatic niche. Due to their role in tumor metastasis, exosomal non-coding RNAs have the potential to serve as diagnostic or prognostic markers as well as therapeutic targets for tumors. The purpose of this paper is to review and discuss the mechanisms of exosomal non-coding RNAs, their role in tumor metastasis, and their clinical utility, aiming to establish new directions for tumor metastasis, diagnosis, and treatment research. [Display omitted] Exosomal non-coding RNAs have been found to play an important role in tumor metastasis. This paper reviews the important functions of exosome non-coding RNAs in tumor microenvironment, tumor immunity, EMT, angiogenesis, lymphangiogenesis, and distant metastasis formation. Exosomal non-coding RNAs may be new tumor biomarkers and therapeutic targets.
ISSN:2162-2531
2162-2531
DOI:10.1016/j.omtn.2022.05.034