Protein Dynamics in F-like Bacterial Conjugation

Efficient in silico development of novel antibiotics requires high-resolution, dynamic models of drug targets. As conjugation is considered the prominent contributor to the spread of antibiotic resistance genes, targeted drug design to disrupt vital components of conjugative systems has been propose...

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Bibliographic Details
Published in:Biomedicines 2020-09, Vol.8 (9), p.362
Main Authors: Bragagnolo, Nicholas, Rodriguez, Christina, Samari-Kermani, Naveed, Fours, Alice, Korouzhdehi, Mahboubeh, Lysenko, Rachel, Audette, Gerald F.
Format: Article
Language:English
Subjects:
bacterial conjugation
F plasmid
pilus protein structure
protein dynamics
protein-protein interactions
Review
type IV secretion system (T4SS)
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Summary:Efficient in silico development of novel antibiotics requires high-resolution, dynamic models of drug targets. As conjugation is considered the prominent contributor to the spread of antibiotic resistance genes, targeted drug design to disrupt vital components of conjugative systems has been proposed to lessen the proliferation of bacterial antibiotic resistance. Advancements in structural imaging techniques of large macromolecular complexes has accelerated the discovery of novel protein-protein interactions in bacterial type IV secretion systems (T4SS). The known structural information regarding the F-like T4SS components and complexes has been summarized in the following review, revealing a complex network of protein-protein interactions involving domains with varying degrees of disorder. Structural predictions were performed to provide insight on the dynamicity of proteins within the F plasmid conjugative system that lack structural information.
ISSN:2227-9059
2227-9059
DOI:10.3390/biomedicines8090362