The prevalence of Helicobacter Pylori infection in patients with obstructive sleep apnea having metabolic syndrome and its relation to both disorders

• Published in: The Egyptian Journal of Bronchology 2017-07, Vol.11 (3), p.268-275
• Main Authors: Banawan, Laila A. H., Daabis, Rasha G. A., Elsheikh, Wafaa H., Tolba, Mona M., Youssef, Amira M.
• Format: Article
• Language: English
• Subjects: Gastroesophageal reflux; gastroesophageal reflux disease; Helicobacter pylori infection; Infections; Insulin resistance; Medicine & Public Health; Metabolic syndrome; obstructive sleep apnea hypopnea syndrome; obstructive sleep apnea hypopnea syndrome severity; Original Article; Sleep apnea
• ISSN: 1687-8426; 2314-8551
• DOI: 10.4103/ejb.ejb_54_16

Introduction Obstructive sleep apnea hypopnea syndrome (OSAHS) is a highly prevalent respiratory disorder and is associated with metabolic syndrome (MS). Helicobacter pylori ( H. pylori ) infection (Hp-I)maybe involved in the pathogenesis of both obstructive sleep apnea (OSA) and gastroesophageal reflux disease(GERD);the latter is alsoassociatedwithOSAHS. Anassociation betweenHp-IandOSAhas beenreportedas well as a potential association between Hp-I and insulin resistance, which represents the pathogenetic basis of MS. Objective To study the prevalence of Hp-I in patients with OSAHS having MS and its relation to both OSAHS and MS and to asses GERD symptoms in the studied groups and its relation to the severity of OSA and to Hp-I. Patients and methods This study included 28 patients with confirmed OSAHS by overnight polysomnography, with half of them having MS. Demographic, comorbidities, anthropometric, and clinical data were collected. Stool analysis for H. pylori antigen was done. Results Patients with OSAHS with MS had significantly more severe OSA ( P ≤0.001*). The prevalence of both Hp-I and GERD was significantly higher in the MS group ( P =0.023 and 0.018, respectively). GERD was significantly associated with H. pylori infection in the studied groups ( P