Chronic wounds treated with cold atmospheric plasmajet versus best practice wound dressings: a multicenter, randomized, non-inferiority trial

The use of phase-adapted wound dressings represents best practice (BP) in chronic wound treatment. However, efficacy is often limited and associated care requirements are high. Cold atmospheric plasmajet (CAP-jet) is a promising new therapeutic tool for these wounds. In the present multicenter, rand...

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Bibliographic Details
Published in:Scientific reports 2022-03, Vol.12 (1), p.3645-3645, Article 3645
Main Authors: Strohal, R., Dietrich, S., Mittlböck, M., Hämmerle, G.
Format: Article
Language:English
Subjects:
692/699/578
692/700/565
Bandages
Etiology
Humanities and Social Sciences
Humans
Medical dressings
multidisciplinary
Patients
pH effects
Prospective Studies
Science
Science (multidisciplinary)
Ulcers
Wound Healing
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Summary:The use of phase-adapted wound dressings represents best practice (BP) in chronic wound treatment. However, efficacy is often limited and associated care requirements are high. Cold atmospheric plasmajet (CAP-jet) is a promising new therapeutic tool for these wounds. In the present multicenter, randomized, open-label, prospective, clinical trial, non-inferiority of the CAP-jet versus BP was assessed in 78 patients with infected or non-infected chronic wounds of different etiology. Primary outcome measure was the sum of granulation tissue, furthermore wound area reduction, healing rate, time to complete healing, changes in wound pH value, infection score, exudate level and local tolerability were assessed. In CAP-jet treated wounds compared to control, the sum of granulation tissue was significantly higher (p 
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-022-07333-x