Diagnostic value of one-stop CT energy spectrum and perfusion for angiogenesis in colon and rectum cancer

• Published in: BMC medical imaging 2024-05, Vol.24 (1), p.116-14, Article 116
• Main Authors: Zhao, Ling, Zhou, Wei, Fu, Yu, Ge, Yanlei, Feng, Li, Wang, Xingwen, Li, Zemao, Chen, Weibin
• Format: Article
• Language: English
• Subjects: Adult; Aged; Aged, 80 and over; Angiogenesis; Blood flow; Blood vessels; Blood volume; Cancer; Colon cancer; Colonic Neoplasms - blood supply; Colonic Neoplasms - diagnostic imaging; Colonoscopy; Colorectal cancer; Colorectal carcinoma; Colorectal Neoplasms - blood supply; Colorectal Neoplasms - diagnostic imaging; Colorectal Neoplasms - pathology; Computed tomography; Coronary vessels; CT imaging; Data collection; Diagnosis; Effectiveness; Energy; Energy spectra; Energy spectrum and perfusion CT parameters; Female; Humans; Image processing; Imaging systems; Intestine; Iodine; Lesions; Male; Malignancy; Medical diagnosis; Medical imaging; Metastases; Metastasis; Microvascular Density; Microvessel density (MVD); Middle Aged; Neovascularization, Pathologic - diagnostic imaging; Parameters; Pathology; Patients; Perfusion; Permeability; Predictive Value of Tests; Rectal Neoplasms - blood supply; Rectal Neoplasms - diagnostic imaging; Rectal Neoplasms - pathology; Retrospective Studies; Software; Spectrum analysis; Statistical analysis; Surgery; Time measurement; Tomography, X-Ray Computed - methods; Transit time; Tumors; Veins & arteries; Visual field; Work stations
• ISSN: 1471-2342; 1471-2342
• DOI: 10.1186/s12880-024-01291-8

Evaluation of the predictive value of one-stop energy spectrum and perfusion CT parameters for microvessel density (MVD) in colorectal cancer cancer foci. Clinical and CT data of 82 patients with colorectal cancer confirmed by preoperative colonoscopy or surgical pathology in our hospital from September 2019 to November 2022 were collected and analyzed retrospectively. Energy spectrum CT images were measured using the Protocols general module of the GSI Viewer software of the GE AW 4.7 post-processing workstation to measure the CT values of the arterial and venous phase lesions and the neighboring normal intestinal wall in a single energy range of 40 kev∼140 kev, and the slopes of the energy spectrum curves (λ) were calculated between 40 kev-90 kev; Iodine concentration (IC), Water concentration (WC), Effective-Z (Eff-Z) and Normalized iodine concentration (NIC) were measured by placing a region of interest (ROI) on the iodine concentration map and water concentration map at the lesion and adjacent to the normal intestinal wall.Perfusion CT images were scanned continuously and dynamically using GSI Perfusion software and analyzed by applying CT Perfusion 4.0 software.Blood volume (BV), blood flow (BF), surface permeability (PS), time to peak (TTP), and mean transit time (MTT) were measured respectively in the lesion and adjacent normal colorectal wall. Based on the pathological findings, the tumors were divided into a low MVD group (MVD