Spontaneous Regression of Merkel Cell Carcinoma: Case Report

Merkel cell carcinoma (MCC) is a rare skin neuroendocrine tumor presumably arising from Merkel cells in the basal layer of epidermis. It is an aggressive tumor predominantly found on the head and neck area of elderly people, with a mortality rate around 41% for all stages. Complete spontaneous regre...

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Bibliographic Details
Published in:International medical case reports journal 2021-10, Vol.14, p.711-717
Main Authors: Bystricky, Branislav, Kohutek, Filip, Miklatkova, Zuzana, Sedlacek, Tomas, Gal, Viliam, Behulova, Regina Lohajova
Format: Article
Language:English
Subjects:
Aged
Biopsy
Cancer
Carcinoma
Case Report
Case reports
Cysts
Disease
Gene mutations
Genes
Genetic aspects
Genomics
Health aspects
Lymphatic system
Medical prognosis
Melanoma
Metastasis
Mortality
Neutrophils
next-generation sequencing
Patients
Sinuses
Skin
Skin cancer
skin neuroendocrine tumor
Slovakia
Surgery
Tumors
zygomatic region
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Summary:Merkel cell carcinoma (MCC) is a rare skin neuroendocrine tumor presumably arising from Merkel cells in the basal layer of epidermis. It is an aggressive tumor predominantly found on the head and neck area of elderly people, with a mortality rate around 41% for all stages. Complete spontaneous regression of MCC is seldom observed, mostly in elderly women. We describe complete spontaneous regression of large, histologically confirmed MCC in an elderly woman after biopsy, which occurred incidentally, while waiting for radical surgery with skin flap. Next-generation sequencing with SOPHiA Solid Tumor Plus Solution did not reveal any relevant gene mutations or rearrangements. An update of literature for these very rare cases is provided. Keywords: skin neuroendocrine tumor, zygomatic region, next-generation sequencing
ISSN:1179-142X
1179-142X
DOI:10.2147/IMCRJ.S329545