Prognostic Gene Predictors of Gestational Diabetes in Endometrium and Follicular Fluid of Women after Infertility

• Published in: Medicina (Kaunas, Lithuania) Lithuania), 2022-03, Vol.58 (4), p.498
• Main Authors: Vaigauskaitė, Brigita, Baušytė, Raminta, Valatkaitė, Elvina, Skliutė, Giedrė, Kazėnaitė, Edita, Ramašauskaitė, Diana, Navakauskienė, Rūta
• Format: Article
• Language: English
• Subjects: Diabetes, Gestational - epidemiology; Diabetes, Gestational - genetics; DNA methylation; Endometrium; Female; Fetuses; Follicular Fluid; Gene expression; Gestational diabetes; gestational diabetes mellitus; Glucose; Humans; Hyperglycemia; Infertility; Infertility - complications; Metabolism; Obesity; Ovulation; Pathogenesis; Patients; Pregnancy; Prognosis; Stem cells; Womens health
• ISSN: 1648-9144; 1010-660X; 1648-9144
• DOI: 10.3390/medicina58040498

Gestational diabetes mellitus is an increasingly diagnosed metabolic disorder during pregnancy with unknown pathological pathways. Taking into account the growing numbers of women who are conceiving after assisted reproductive technologies, they comprise an engaging target group for gestational diabetes mellitus etiopathogenesis research. In terms of metabolism and genetics, as the evidence shows, both unexplained infertility and gestational diabetes mellitus pose challenges for their interpretation due to the complex bodily processes. Our study examined the expression of genes ( ) associated with glucose metabolism in unexplained infertility patients who conceived after in vitro fertilization procedure, were diagnosed with GDM and their findings were compared with control population. . There were no significant differences in gene expression of endometrium stromal cells between healthy pregnant women and women with gestational diabetes, although the significant downregulation of was observed in the follicular fluid of women with gestational diabetes mellitus. Moreover, expression of and was significantly reduced in FF cells when compared to endometrial cells. These findings may indicate about the importance of follicular fluid as an indicator for gestational diabetes and should be explored more by further research.