The prognostic significance of tumor spread through air space in stage I lung adenocarcinoma

Aim There are still patients of stage I lung adenocarcinoma (ADC) suffering from local or distant recurrence. Herein we conducted a meta‐analysis to investigate the prognostic value of tumor spread through air space (STAS), a new form of invasion pattern, in patients with pathologically confirmed st...

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Bibliographic Details
Published in:Thoracic cancer 2022-04, Vol.13 (7), p.997-1005
Main Authors: Huang, Liling, Tang, Le, Dai, Liyuan, Shi, Yuankai
Format: Article
Language:English
Subjects:
Adenocarcinoma of Lung - pathology
Adenocarcinoma of Lung - surgery
Humans
lung adenocarcinoma
Lung cancer
Lung Neoplasms - pathology
Meta-analysis
Neoplasm Invasiveness - pathology
Neoplasm Recurrence, Local - pathology
Neoplasm Staging
Original
Prognosis
Retrospective Studies
Sensitivity analysis
spread through air space
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Summary:Aim There are still patients of stage I lung adenocarcinoma (ADC) suffering from local or distant recurrence. Herein we conducted a meta‐analysis to investigate the prognostic value of tumor spread through air space (STAS), a new form of invasion pattern, in patients with pathologically confirmed stage I lung ADC. Methods Related literature was searched using PubMed, Embase, Cochrane Library, and Web of Science databases from the inception dates to September 4, 2021. Recurrence‐free survival (RFS) and overall survival (OS) were set as primary outcome endpoints. In addition, subgroup analyses on operation mode, edition of the American Joint Committee on Cancer TNM staging, sample size, and research regions were also investigated. Results A total of 17 studies involving 9785 patients were included. The presence of STAS was detected in 31.2% of patients and was associated with poor RFS (adjusted hazard ratio [HR] = 1.93, p 
ISSN:1759-7706
1759-7714
1759-7714
DOI:10.1111/1759-7714.14348