New Sorbicillinoids from the Mangrove Endophytic Fungus Trichoderma reesei SCNU-F0042

Three new dimeric sorbicillinoids (1–3) and one new 3,4,6-trisubstituted α-pyrone (5), along with seven analogues (4 and 6–11), were isolated from the mangrove endophytic fungus Trichoderma reesei SCNU-F0042 under the guidance of molecular networking approach. Their chemical structures were establis...

Full description

Saved in:
Bibliographic Details
Published in:Marine drugs 2023-08, Vol.21 (8), p.442
Main Authors: Li, Jialin, Chen, Tao, Yu, Jianchen, Jia, Hao, Chen, Chen, Long, Yuhua
Format: Article
Language:English
Subjects:
Bio-assays
Bioassays
Endophytes
Fungi
mangrove endophytic fungus
Mangroves
Metabolites
molecular networking
NMR
Nuclear magnetic resonance
SARS-CoV-2 inhibitory activity
Severe acute respiratory syndrome coronavirus 2
sorbicillinoids
Spectrum analysis
Trichoderma reesei
Two dimensional analysis
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Three new dimeric sorbicillinoids (1–3) and one new 3,4,6-trisubstituted α-pyrone (5), along with seven analogues (4 and 6–11), were isolated from the mangrove endophytic fungus Trichoderma reesei SCNU-F0042 under the guidance of molecular networking approach. Their chemical structures were established by 1D and 2D NMR HR-ESI-MS and ECD analysis. In a bioassay, compound 2 exhibited moderate SARS-CoV-2 inhibitory activity with an EC50 value of 29.0 μM.
ISSN:1660-3397
1660-3397
DOI:10.3390/md21080442