Regenerative Medicine and Angiogenesis; Challenges and Opportunities

Blood vessel development is one of the most prominent steps in regenerative medicine due tothe restoration of blood flow to the ischemic tissues and providing the rapid vascularizationin clinical-sized tissue-engineered grafts. However, currently tissue engineering technique isrestricted because of...

Full description

Saved in:
Bibliographic Details
Published in:Advanced pharmaceutical bulletin 2020-08, Vol.10 (4), p.490-501
Main Authors: Jahani, Mozhgan, Rezazadeh, Davood, Mohammadi, Parisa, Abdolmaleki, Amir, Norooznezhad, Amir, Mansouri, Kamran
Format: Article
Language:English
Subjects:
Angiogenesis
Blood platelets
Gene expression
Genetic engineering
In vitro fertilization
Kinases
Medicine
regenerative medicine
Review
scaffold
Stem cells
Tissue engineering
Transplants & implants
Vascular endothelial growth factor
Wound healing
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Blood vessel development is one of the most prominent steps in regenerative medicine due tothe restoration of blood flow to the ischemic tissues and providing the rapid vascularizationin clinical-sized tissue-engineered grafts. However, currently tissue engineering technique isrestricted because of the inadequate in vitro/in vivo tissue vascularization. Some challenges likeas transportation in large scale, distribution of the nutrients and poor oxygen diffusion limit theprogression of vessels in smaller than clinically relevant dimensions as well in vivo integration.In this regard, the scholars attempted to promote the vascularization process relied on the stemcells (SCs), growth factors as well as exosomes and interactions of biomaterials with all of themto enable the emergence of ideal microenvironment which is needed for treatment of unhealthyorgans or tissue regeneration and formation of new blood vessels. Thus, in the present reviewwe aim to describe these approaches, advances, obstacles and opportunities as well as theirapplication in regeneration of heart as a prominent angiogenesis-dependent organ.
ISSN:2228-5881
2251-7308
DOI:10.34172/apb.2020.061