The reversal of drug-resistance in tumors using a drug-carrying nanoparticular system

Medical applications of nanoparticular systems have attracted considerable attention because of their potential use in therapeutic targeting of disease tissues and their lower level of toxicity against healthy tissue, relative to traditional pharmaceutical drugs. The use of nanoparticular systems ha...

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Bibliographic Details
Published in:International journal of molecular sciences 2009-08, Vol.10 (9), p.3776-3792
Main Authors: Oh, Kyung Taek, Baik, Hye Jung, Lee, A Hyeong, Oh, Young Taik, Youn, Yu Seok, Lee, Eun Seong
Format: Article
Language:English
Subjects:
Animals
Antineoplastic Agents - administration & dosage
Antineoplastic Agents - chemistry
Antineoplastic Agents - pharmacology
Antineoplastic Agents - therapeutic use
Doxorubicin - chemistry
Doxorubicin - pharmacology
Doxorubicin - therapeutic use
drug delivery system
Drug Resistance, Neoplasm
Drug Screening Assays, Antitumor
Humans
multi-drug resistance
Nanocapsules - chemistry
Nanocapsules - therapeutic use
nanoparticle
Neoplasms - drug therapy
Neoplasms - pathology
Review
Tumor Microenvironment - drug effects
tumor treatment
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Summary:Medical applications of nanoparticular systems have attracted considerable attention because of their potential use in therapeutic targeting of disease tissues and their lower level of toxicity against healthy tissue, relative to traditional pharmaceutical drugs. The use of nanoparticular systems has been shown to overcome the limitations of most anticancer drugs in clinical applications. In particular, the improved performance of smarted nanoparticular system for solving the drug resistance problems that typically interrupt tumor treatment has provided a promising strategy for successful tumor chemotherapy. This review highlights recent studies that have examined the therapeutic effect of nanoparticular systems on drug-resistant tumors and presents insight on how they work.
ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms10093776