The Use of Acellular Fish Skin Grafts in Burn Wound Management-A Systematic Review

Burn wound healing and management continues to be a major challenge for patients and health care providers resulting in a considerable socio-economic burden. Recent advances in the development of applicable xenografts as an alternative to split-thickness skin grafts have allowed for the development...

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Published in:Medicina (Kaunas, Lithuania) Lithuania), 2022-07, Vol.58 (7), p.912
Main Authors: Luze, Hanna, Nischwitz, Sebastian Philipp, Smolle, Christian, Zrim, Robert, Kamolz, Lars-Peter
Format: Article
Language:English
Subjects:
acellular fish skin
Animals
Aquaculture
Biological Dressings
burn injury
burn wound management
Burns
Burns - surgery
Fatty acids
fish skin grafts
Fishes
Humans
Injuries
Investigations
Plastic surgery
Plastic Surgery Procedures
Skin & tissue grafts
Systematic Review
Tilapia
Treatment Outcome
Wound healing
Wound Healing - physiology
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Summary:Burn wound healing and management continues to be a major challenge for patients and health care providers resulting in a considerable socio-economic burden. Recent advances in the development of applicable xenografts as an alternative to split-thickness skin grafts have allowed for the development of acellular fish skin. Acellular fish skin acts as a skin substitute, reducing inflammatory responses and advancing proinflammatory cytokines that promote wound healing. Due to these beneficial wound healing properties, acellular fish skin might represent an effective treatment approach in burn wound management. A systematic review of the literature, up to March 2022, was conducted using the electronic databases PubMed and Web of Science. Titles and abstracts were screened for the following key terms (variably combined): "fish skin", "fish skin grafts", "acellular fish skin", "Omega3 Wound matrix", "xenograft", "burn injury", "burns". In total, 14 trials investigating the effects of acellular fish skin in burn wounds or split-thickness donor sites were determined eligible and included in the present review. Existing evidence on the use of acellular fish skin indicates an acceleration of wound healing, reduction in pain and necessary dressing changes as well as treatment-related costs and improved aesthetic and functional outcomes compared to conventional treatment options. Acellular fish skin xenografts may represent an effective, low-cost alternative in treatment of superficial- and partial-thickness burns. However, results mainly originate from preclinical and small cohort studies. Future larger cohort studies are warranted to elucidate the full potential of this promising approach.
ISSN:1648-9144
1010-660X
1648-9144
DOI:10.3390/medicina58070912