Expression of PD-1 on CD4+ Tumor-Infiltrating Lymphocytes in Tumor Microenvironment Associated with Pathological Characteristics of Breast Cancer

• Published in: Journal of immunology research 2018-01, Vol.2018 (2018), p.1-8
• Main Authors: Li, Ying-Nan, Song, Qingkun, Chang, Hong, Wang, Rui-Bin, Wu, Guangjiang, Wu, Jiangping, Hu, Zhi-Ping, Shi, Feng, Zhang, Jian, Zhao, Yanjie, Zhou, Quan
• Format: Article
• Language: English
• Subjects: Adult; Aged; Antigens; Apoptosis; Breast cancer; Breast Neoplasms - immunology; Breast Neoplasms - pathology; Carcinoma, Ductal, Breast - immunology; Carcinoma, Ductal, Breast - pathology; CD4 antigen; CD4-Positive T-Lymphocytes - immunology; Cell cycle; Cell death; Color; Correlation coefficient; Correlation coefficients; Cross-Sectional Studies; Cytoplasm; E-cadherin; Ethics; Female; Geriatrics; Humans; Immunohistochemistry; Immunology; Immunomodulation; Invasiveness; Lymphocytes; Lymphocytes T; Lymphocytes, Tumor-Infiltrating - immunology; Medical prognosis; Middle Aged; Older people; PD-1 protein; Phenotypes; Programmed Cell Death 1 Receptor - biosynthesis; Programmed Cell Death 1 Receptor - immunology; Retrospective Studies; T-Lymphocyte Subsets - immunology; Tumor Microenvironment - immunology; Tumor-infiltrating lymphocytes; Working groups
• ISSN: 2314-8861; 2314-7156
• DOI: 10.1155/2018/5690258

Objective. This study aimed to investigate the correlation of CD4+/PD-1+ or CD4+/PD-1− tumor-infiltrating lymphocytes with pathological characteristics in breast cancer patients. Methods. A cross-sectional study consecutively recruited 133 patients with invasive ductal breast cancer. The expression of CD4, programmed cell death protein 1 (PD-1), CK7, CK20, E-cadherin, or Ki-67 was detected by immunohistochemistry. The associations between CD4+/PD-1+ or CD4+/PD-1− tumor-infiltrating lymphocytes and pathological characteristics were evaluated. Results. Elderly patients intended to have a lower level of CD4+/PD-1− tumor-infiltrating lymphocytes (p